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O(6)-n-butylguanine

Known as: O(6)-butylguanine 
National Institutes of Health

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Related topics

2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

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2006
2006
Effect of 06-Alkylguanine Pretreatment on the Sensitivity of Human Colon Tumor Cells to the Cytotoxic Effects of Chloroethy lating Agents1
Two human colon carcinoma cell lines which differ greatly in their content of O'-alkylguanine-DNA alkyltransferase were analyzed… 
2005
2005
Site-specific mutagenesis induced by single O 6-alkylguanines ( O 6n-propyl , O 6n-butyl , O 6n-octyl ) in vivo
The mutagenlc activity of a series of longer chain O-n-alkylguanine residues (O^n-propyl, O-n-butyl, O-n-octyl) has been analyzed… 
1994
1994
Detection of O6-butyl- and O6-(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl(4-hydroxybutyl)amine.
N-Nitrosobutyl(4-hydroxybutyl)amine (BBN) is a selective bladder carcinogen in rats. Its organ specificity may depend on several… 
Highly Cited
1985
Highly Cited
1985
Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.
Exposure of HeLa cells to 0.2 mM O6-methylguanine for 4 h or longer led to a 70-80% loss in the activity of the DNA-repair… 
Highly Cited
1985
Highly Cited
1985
Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.
1985
1985
uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.
Using site-specific mutagenesis, we have examined the mutagenic activity in vivo of O6-methylguanine or O6-n-butylguanine located… 
1980
1980
Reaction of N-n-butyl-N-nitrosourea with DNA in vitro.
N-n-[1-14C]Butyl-N-nitrosourea was synthesized from n-[1-14C]butanol and incubated at physiological conditions (pH 7.2; 37… 
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