O(6)-benzylguanine

Known as: 2-amino-6-(phenylmethoxy)-9h-purine, BG, o6 benzylguanine 
A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central nervous system. Treatment includes… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Over the past few years, the alkylating agent temozolomide has become the standard-of-care therapy for patients with… (More)
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Highly Cited
2007
Highly Cited
2007
Methylating drugs such as temozolomide (TMZ) are widely used in the treatment of brain tumours (malignant gliomas). The mechanism… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE In this study, we investigated the mechanisms by which temozolomide enhances radiation response in glioblastoma cells… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE In the setting of a prospective clinical trial, we determined the predictive value of the methylation status of the O-6… (More)
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Review
2002
Review
2002
Anumber of DNA-damaging chemotherapeutic agents attack the O(6) position on guanine, forming the most potent cytotoxic DNA… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE We conducted a two-phase clinical trial in patients with progressive malignant glioma (MG). The first phase of this trial… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE Prior studies show that increased levels of the DNA repair protein O6 methylguanine-DNA methyltransferase (MGMT), also… (More)
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Highly Cited
1991
Highly Cited
1991
The effect of O6-benzylguanine, O6-(p-chlorobenzyl)guanine, and O6-(p-methylbenzyl)guanine on the sensitivity of various human… (More)
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Highly Cited
1990
Highly Cited
1990
O6-Alkylguanine-DNA alkyltransferase was rapidly and irreversibly inactivated by exposure to O6-benzylguanine or the p… (More)
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