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O(4)-ethylthymidine

Known as: O(4)-ethyl-2'-deoxythymidine, O(4)-ethyldeoxythymidine 
National Institutes of Health

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2 relations

Broader (1)

Thymidine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Analysis of ethylated thymidine adducts in human leukocyte DNA by stable isotope dilution nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry.
Studies showed that levels of ethylated DNA adducts in certain tissues and urine are higher in smokers than in nonsmokers… 
2011
2011
Smoking-related O4-ethylthymidine formation in human lung tissue and comparisons with bulky DNA adducts.
Tobacco smoke contains many alkylating agents that can react with DNA to produce O(4)-ethylthymidine (O(4)-etT) and several other… 
Highly Cited
2002
Highly Cited
2002
Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking.
Cigarette smokers inhale a broad range of carcinogens derived from tobacco and its pyrolysis products, including free radicals… 
1993
1993
Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence.
We report the establishment of a standardized, monoclonal antibody (Mab)-based immunocytological assay (quantitative ICA) for the… 
1989
1989
Immunoanalytical detection of O4-ethylthymine in liver DNA of individuals with or without malignant tumors.
The detection and quantitation of carcinogen-DNA adducts in human cells are the key parameters in the molecular dosimetry of… 
Highly Cited
1987
Highly Cited
1987
Molecular dosimetry of O4-ethyldeoxythymidine in rats continuously exposed to diethylnitrosamine.
There is considerable interest in incorporating mechanistically based biological data into the process of quantitative risk… 
1987
1987
Immunological quantitation of O4-ethylthymidine in alkylated DNA: repair of minor miscoding base in human cells.
Rabbit antisera specific for O4-ethyldeoxythymidine (O4-EtdThd) were developed and used in competitive and non-competitive… 
Highly Cited
1986
Highly Cited
1986
Correlation of O4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine.
Recent experiments have demonstrated that O6-ethyldeoxyguanosine (O6-EtdG) is efficiently repaired while O4-ethyldeoxythymidine… 
1986
1986
Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis.
Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma… 
Highly Cited
1984
Highly Cited
1984
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine.
In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated… 
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