O(4)-ethylthymidine

Studies showed that levels of ethylated DNA adducts in certain tissues and urine are higher in smokers than in nonsmokers… Expand

Tobacco smoke contains many alkylating agents that can react with DNA to produce O(4)-ethylthymidine (O(4)-etT) and several other… Expand

Cigarette smokers inhale a broad range of carcinogens derived from tobacco and its pyrolysis products, including free radicals… Expand

We report the establishment of a standardized, monoclonal antibody (Mab)-based immunocytological assay (quantitative ICA) for the… Expand

The detection and quantitation of carcinogen-DNA adducts in human cells are the key parameters in the molecular dosimetry of… Expand

There is considerable interest in incorporating mechanistically based biological data into the process of quantitative risk… Expand

Recent experiments have demonstrated that O6-ethyldeoxyguanosine (O6-EtdG) is efficiently repaired while O4-ethyldeoxythymidine… Expand

Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma… Expand

In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated… Expand

In order to compare the kinetics of their enzymatic elimination from the DNA of liver, kidney, lung, and brain, the alkylation… Expand