O(4)-ethylthymidine

Exposure to environmental agents and endogenous metabolism can both give rise to DNA alkylation. Thymine is known to be alkylated… Expand

Smoking cigarette increases levels of certain ethylated DNA adducts in certain tissues and urine. Cigarette smoking is a major… Expand

Causal links exist between smoking cigarettes and cancer development. Some genotoxic agents in cigarette smoke are capable of… Expand

Studies showed that levels of ethylated DNA adducts in certain tissues and urine are higher in smokers than in nonsmokers… Expand

Cigarette smokers inhale a broad range of carcinogens derived from tobacco and its pyrolysis products, including free radicals… Expand

The detection and quantitation of carcinogen-DNA adducts in human cells are the key parameters in the molecular dosimetry of… Expand

Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma… Expand

In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated… Expand

SummaryWe have established a highly sensitive immuno-slot-blot (ISB) procedure that can be routinely applied for detection and… Expand

In order to compare the kinetics of their enzymatic elimination from the DNA of liver, kidney, lung, and brain, the alkylation… Expand