Nuclear Factor of Activated T-Cells, Cytoplasmic 1

Known as: NFATc, NFATc1, NFAT Transcription Complex Cytosolic Component 
Nuclear factor of activated T-cells, cytoplasmic 1 (943 aa, ~101 kDa) is encoded by the human NFATC1 gene. This protein plays a role in the… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts… (More)
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Highly Cited
2006
Highly Cited
2006
Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key mediator in proximal signaling of the interleukin-1… (More)
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Highly Cited
2006
Highly Cited
2006
Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic… (More)
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Highly Cited
2005
Highly Cited
2005
Bone homeostasis depends on the coordination of osteoclastic bone resorption and osteoblastic bone formation. Receptor activator… (More)
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Highly Cited
2004
Highly Cited
2004
The receptor activator of NF-kappaB ligand (RANKL) induces various osteoclast-specific marker genes during osteoclast… (More)
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Highly Cited
2002
Highly Cited
2002
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos… (More)
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Highly Cited
2002
Highly Cited
2002
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor… (More)
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Highly Cited
1998
Highly Cited
1998
The c-Jun NH2-terminal kinase (JNK) signaling pathway has been implicated in the immune response that is mediated by the… (More)
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1998
1998
Tpl-2 expression is induced within 30-60 min after ConA stimulation of rat splenocytes, suggesting that it may contribute to the… (More)
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Highly Cited
1995
Highly Cited
1995
The nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located… (More)
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