Nonsense Mediated mRNA Decay

Known as: mRNA degradation, nonsense-mediated decay, NMD, mRNA breakdown, nonsense-mediated decay 
Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
In mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that translation terminates sufficiently upstream of a… (More)
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Highly Cited
2008
Highly Cited
2008
The nonsense-mediated decay (NMD) pathway subjects mRNAs with premature termination codons (PTCs) to rapid decay. The conserved… (More)
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Highly Cited
2008
Highly Cited
2008
Nonsense-mediated mRNA decay (NMD) is a quality control system that degrades mRNAs containing premature termination codons… (More)
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Review
2008
Review
2008
Alternative splicing (AS) strongly affects gene expression by generating protein isoform diversity. However, up to one-third of… (More)
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Review
2007
Review
2007
Most human genes exhibit alternative splicing, but not all alternatively spliced transcripts produce functional proteins… (More)
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Highly Cited
2006
Highly Cited
2006
Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway that selectively degrades aberrant mRNAs with… (More)
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Review
2005
Review
2005
Nonsense-mediated mRNA decay (NMD) generally involves nonsense codon recognition by translating ribosomes at a position… (More)
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Highly Cited
2004
Highly Cited
2004
Nonsense-mediated messenger RNA decay (NMD) is triggered by premature translation termination, but the features distinguishing… (More)
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Highly Cited
2003
Highly Cited
2003
To better understand the role of alternative splicing, we conducted a large-scale analysis of reliable alternative isoforms of… (More)
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Review
2002
Review
2002
many quality control mechanisms developed by cells to maintain the metabolic status quo. The cell’s objective in this case is to… (More)
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