Nondisjunction, Genetic

Known as: Non-Disjunction, Genetic, Nondisjunctions, Genetic, Genetic Non Disjunction 
The failure of homologous CHROMOSOMES or CHROMATIDS to segregate during MITOSIS or MEIOSIS with the result that one daughter cell has both of a pair… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
Although mutations in cell cycle regulators or spindle proteins can perturb chromosome segregation, the causes and consequences… (More)
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Highly Cited
2005
Highly Cited
2005
Mitotic chromosome segregation is facilitated by the cohesin complex, which maintains physical connections between sister… (More)
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Highly Cited
1997
Highly Cited
1997
A checkpoint mechanism operates at the metaphase/anaphase transition to ensure that a bipolar spindle is formed and that all the… (More)
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Highly Cited
1997
Highly Cited
1997
Recent studies of trisomy 21 have shown that altered levels of recombination are associated with maternal non-disjunction… (More)
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Highly Cited
1996
Highly Cited
1996
The relationship between advanced maternal age and increased risk of trisomic offspring is well known clinically but not clearly… (More)
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Highly Cited
1995
Highly Cited
1995
The centromere, a differentiated region of the eukaryotic chromosome, mediates the segregation of sister chromatids at mitosis… (More)
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Highly Cited
1989
Highly Cited
1989
The hypothesis that DNA topoisomerase II facilitates the separation of replicated sister chromatids was tested by examining the… (More)
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Highly Cited
1985
Highly Cited
1985
A colony color assay that measures chromosome stability is described and is used to study several parameters affecting the… (More)
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Highly Cited
1983
Highly Cited
1983
Inheritance of a mutation at the Rb-1 locus, which has been mapped to band q14 of human chromosome 13, results in predisposition… (More)
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Highly Cited
1979
Highly Cited
1979
The frequency of males (5AA; XO) among the self progeny of wild-type Caenorhabditis elegans hermaphrodites (5AA; XX) is about one… (More)
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