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Non-nucleoside Reverse Transcriptase Inhibitor

Known as: NNRTI 
A substance structurally unlike a nucleoside molecule that is capable of inhibiting the function of a reverse transcriptase. These compounds do not… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Rilpivirine resistance mutations in HIV patients failing non-nucleoside reverse transcriptase inhibitor-based therapies
Objective:Rilpivirine (RPV) is the latest approved nonnucleoside reverse transcriptase inhibitor (NNRTI). It displays in-vitro… 
Highly Cited
2007
Highly Cited
2007
HIV-1 Reverse Transcriptase Plus-strand Initiation Exhibits Preferential Sensitivity to Non-nucleoside Reverse Transcriptase Inhibitors in Vitro*
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human… 
Highly Cited
2007
Highly Cited
2007
Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance
We determined whether methamphetamine use is associated with the increased prevalence of primary HIV drug resistance among a… 
Highly Cited
2006
Highly Cited
2006
Structural insights into mechanisms of non‐nucleoside drug resistance for HIV‐1 reverse transcriptases mutated at codons 101 or 138
Lys101Glu is a drug resistance mutation in reverse transcriptase clinically observed in HIV‐1 from infected patients treated with… 
2004
2004
Therapeutic drug monitoring of lopinavir/ritonavir given alone or with a non-nucleoside reverse transcriptase inhibitor.
AIMS To evaluate the interindividual variability in the plasma concentrations of lopinavir in the context of routine monitoring… 
Review
2003
Review
2003
HIV Resistance to Nevirapine and Other Non‐Nucleoside Reverse Transcriptase Inhibitors
&NA; Nevirapine and other members of the non‐nucleoside reverse transcriptase inhibitor (NNRTI) family of anti‐HIV‐1 drugs are… 
Highly Cited
2003
Highly Cited
2003
The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro.
Several antiretroviral compounds have been shown to be substrates for the efflux protein P-glycoprotein (P-gp) although few… 
Highly Cited
2003
Highly Cited
2003
The Effect of HAART and HCV Infection on the Development of Hyperglycemia Among HIV‐Infected Persons
Objective: To examine the prevalence and incidence of hyperglycemia among HIV‐infected patients by hepatitis C virus (HCV… 
Highly Cited
2001
Highly Cited
2001
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy
BackgroundEnhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in… 
Highly Cited
1995
Highly Cited
1995
Effects of Non-nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 in Cell-free Recombinant Reverse Transcriptase Assays (*)
We have employed a cell-free human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) assay to study the effects of… 
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