Non-Stop Decay

Known as: nonstop mRNA decay, nuclear-transcribed mRNA catabolic process, non-stop decay, nuclear-transcribed mRNA breakdown, non-stop decay 
In eukaryotes, the non-stop decay mechanism recognizes and degrades mRNAs that lack a stop codon. It releases ribosomes stalled at the 3' end of a… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Reactive oxygen species (ROS) are toxic by-products of normal aerobic metabolism. ROS can damage mRNAs and the translational… (More)
Is this relevant?
2013
2013
In yeast, aberrant mRNAs lacking in-frame termination codons are recognized and degraded by the non-stop decay (NSD) pathway. The… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2012
Highly Cited
2012
There are three predominant forms of co-translational mRNA surveillance: nonsense-mediated decay (NMD), no-go decay (NGD) and… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2011
Highly Cited
2011
NRAS is frequently mutated in hematologic malignancies. We generated Mx1-Cre, Lox-STOP-Lox (LSL)-Nras(G12D) mice to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
No-go decay (NGD) and non-stop decay (NSD) are eukaryotic surveillance mechanisms that target mRNAs on which elongation complexes… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Members of the eukaryote/archaea specific eRF1 and eRF3 protein families have central roles in translation termination. They are… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
A fundamental aspect of the biogenesis and function of eukaryotic messenger RNA is the quality control systems that recognize and… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Review
2002
Review
2002
Gene expression is an inherently complex process and errors often occur during the transcription and processing of mRNAs. Several… (More)
Is this relevant?
1971