Skip to search formSkip to main contentSkip to account menu

Nociceptin, human

Known as: Nociceptin, PPNOC, orphanin FQ 
Nociceptin (17 aa, ~2 kDa) is encoded by the human PNOC gene. This protein plays a role in the perception of pain.
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Endogenous Opiatesnociceptin
NociceptionNociceptorsOpioid ReceptorPNOC gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Binding of the novel radioligand [3H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptors
Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ peptide receptor (NOP). Binding studies have relied on… 
2006
2006
The Involvement of the Nociceptin Receptor in the Antinociceptive Action of Nitrous Oxide
Nociceptin and its receptor are widely expressed in the central nervous system and are involved in the modulation of nociception… 
2004
2004
Molecular mechanisms underlying calcium current modulation by nociceptin
Nociceptin is a non-opioid peptide that modulates pain response. One of mechanism underlying its analgesic action is the… 
2002
2002
[Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat.
The purpose of this study was to investigate the effects of [Nphe1]nociceptin(1-13)-NH2 on nociceptin-induced decreases in mean… 
2001
2001
Postsynaptic K+ current induced by nociceptin in medullary dorsal horn neurons
The actions of the endogenous ORL1 receptor (opioid receptor-like1) ligand nociceptin on the membrane properties of rat… 
2001
2001
Participation of NK1 receptors in nociceptin-induced modulation of rat knee joint mechanosensitivity
Abstract. Nociceptin is known to act peripherally in the rat knee joint to modulate articular mechanosensitivity and it has been… 
2000
2000
Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats.
The effects of central administration of the opioid-like peptide nociceptin (also known as orphanin FQ) were investigated on the… 
1999
1999
Nociceptin binding sites in frog (Rana esculenta) brain membranes.
The recently discovered natural heptadecapeptide nociceptin (orphanin FQ) shares some homology with the opioid peptides but it… 
1998
1998
Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships
1 The present study describes the labelling of the nociceptin (NC) receptor, ORL1, in mouse forebrain membranes with a new ligand… 
Highly Cited
1997
Highly Cited
1997
Naloxone‐insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea‐pig trachea by the novel opioid, nociceptin
The novel peptide, nociceptin and the μ‐opioid agonist [d‐Ala2, N‐Me‐Phe4, Gly5‐ol]‐enkephalin (DAMGO) produced a concentration… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)