Nociceptin, human

Known as: Nociceptin, PPNOC, orphanin FQ 
Nociceptin (17 aa, ~2 kDa) is encoded by the human PNOC gene. This protein plays a role in the perception of pain.
National Institutes of Health

Papers overview

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Review
2000
Review
2000
Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand of the opioid receptor-like 1 receptor… (More)
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Highly Cited
1998
Highly Cited
1998
The peptide nociceptin (also named orphanin FQ) acts in the brain to produce various pharmacological effects, including… (More)
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Review
1998
Review
1998
The publication of the delta opioid receptor sequence led to the cloning of three homologous receptors: the mu and kappa opioid… (More)
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Highly Cited
1998
Highly Cited
1998
[Phe1psi(CH2-NH)Gly2]NC(1-13)NH2 has been tested in the electrically stimulated guinea pig ileum and mouse vas deferens, two… (More)
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Review
1997
Review
1997
Homology cloning and, more recently, the sequencing of whole genomes, have identified many open reading frames encoding proteins… (More)
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Highly Cited
1997
Highly Cited
1997
Orphanin FQ (OFQ, Nociceptin) is a recently discovered 17-amino acid neuropeptide that is structurally related to the opioid… (More)
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Highly Cited
1997
Highly Cited
1997
The newly discovered peptide nociceptin/orphanin FQ has been found to increase reactivity to pain and to influence locomotor… (More)
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Highly Cited
1997
Highly Cited
1997
In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid… (More)
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Highly Cited
1997
Highly Cited
1997
Nociceptin (NC) and some of its fragments as well as nociceptin-(1-13)-peptide amide [NC- (1-13)-NH2] and a series of its… (More)
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Highly Cited
1996
Highly Cited
1996
1. In this study we have examined the effects of nociceptin, an endogenous ligand for the opioid-like receptor ORL1 on the… (More)
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