Nitrosoguanidines

Known as: Nitrosoguanidines [Chemical/Ingredient], nitrosoguanidine 
Nitrosylated derivatives of guanidine. They are used as MUTAGENS in MOLECULAR BIOLOGY research.
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Methylating drugs such as temozolomide (TMZ) are widely used in the treatment of brain tumours (malignant gliomas). The mechanism… (More)
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Highly Cited
2004
Highly Cited
2004
Extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) by DNA damage is a major cause of caspase-independent cell death… (More)
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Highly Cited
1998
Highly Cited
1998
We have demonstrated recently that chronic hyperoxic treatment accelerates the rate of aging of fibroblasts and the rate of… (More)
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Highly Cited
1996
Highly Cited
1996
Selection of cells for resistance to cisplatin, a well-recognized mutagen, could result in mutations in genes involved in DNA… (More)
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Highly Cited
1994
Highly Cited
1994
The human colon tumor cell line HCT 116 is known to have a homozygous mutation in the mismatch repair gene hMLH1 on human… (More)
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Highly Cited
1994
Highly Cited
1994
Curcumin (diferuloylmethane), a yellow pigment that is obtained from the rhizomes of Curcuma longa Linn., is a major component of… (More)
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Highly Cited
1991
Highly Cited
1991
A mutant strain of Helicobacter pylori with weak urease activity was created by using N-methyl-N'-nitro-N-nitrosoguanidine. The… (More)
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Review
1989
Review
1989
About 10 years ago we discovered that bubbling nitric oxide (NO) gas into KrebsRinger bicarbonate solution containing isolated… (More)
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Highly Cited
1970
Highly Cited
1970
1. In neutral aqueous solution N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) yields salts of nitrocyanamide as u.v.-absorbing… (More)
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Highly Cited
1967
Highly Cited
1967
WE reported1 that the subcutaneous injection of a potent mutagen2, N-methyl-N′-nitro-N-nitrosoguanidine (NG), into rats induced… (More)
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