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Nitric Oxide Synthase Inhibitor

Known as: NOS Inhibitor, Nitric Oxide Synthetase Inhibitor 
Any substance that inhibits nitric oxide synthase, an enzyme that catalyzes the production of nitric oxide from L-arginine. Nitric oxide is an… 
National Institutes of Health

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Nitric Oxide Synthase Inhibitors [MoA]inhibitorsnitric-oxide synthase inhibitor activity

Papers overview

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Highly Cited
2005
Highly Cited
2005
Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease
In recent years an important role has been ascribed to a reduced nitric oxide (NO) availability in the pathophysiology of sickle… 
Highly Cited
2002
Highly Cited
2002
The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol
In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol… 
Highly Cited
2001
Highly Cited
2001
Long-term fructose feeding impairs vascular relaxation in rat mesenteric arteries.
Highly Cited
1999
Highly Cited
1999
Expression and action of cyclic GMP-dependent protein kinase Iα in inflammatory hyperalgesia in rat spinal cord
Highly Cited
1997
Highly Cited
1997
The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The neurodegenerative properties of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are… 
Highly Cited
1996
Highly Cited
1996
Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase.
In patients with septic shock or inflammatory cardiac diseases like myocarditis myocardial contractility is depressed. These… 
Highly Cited
1995
Highly Cited
1995
Detrimental effects of a nitric oxide synthase inhibitor (N-omega-nitro-L-arginine-methyl-ester) in a murine sepsis model.
OBJECTIVE To examine the effects of a nitric oxide synthase inhibitor on host elimination of bacteria, tumor necrosis factor (TNF… 
Highly Cited
1995
Highly Cited
1995
Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level.
We investigated the role of nitric oxide (NO) in the expression of interleukin-8 (IL-8) in the human melanoma cell line, G361… 
Highly Cited
1994
Highly Cited
1994
SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors.
We sought to determine whether the attenuation of the hypercapnic cerebrovasodilation associated with inhibition of nitric oxide… 
Highly Cited
1993
Highly Cited
1993
N-methyl-d-aspartate-induced nitric oxide release: An in vivo microdialysis study
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