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Nimustine Hydrochloride

Known as: 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride, ACNU HCl, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea Hydrochloride 
The hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA… 
National Institutes of Health

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Nimustine

Papers overview

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2018
2018
Machine-Learning Approach for Modeling Myelosuppression Attributed to Nimustine Hydrochloride.
PURPOSE A major adverse effect arising from nimustine hydrochloride (ACNU) therapy for brain tumors is myelosuppression. Because… 
2012
2012
Nimustine hydrochloride: the first crystal structure determination of a 2-chloroethyl-N-nitrosourea hydrochloride derivative by X-ray powder diffraction and solid-state NMR.
Nimustine hydrochloride [systematic name: 4-amino-5-({[N-(2-chloroethyl)-N-nitrosocarbamoyl]amino}methyl)-2-methylpyrimidin-1-ium… 
2007
2007
Long-term Follow-up of Busulfan, Etoposide, and Nimustine Hydrochloride (ACNU) or Melphalan as Conditioning Regimens for Childhood Acute Leukemia and Lymphoma
We retrospectively evaluated early and long-term complications of an intensified conditioning regimen consisting of busulfan and… 
2007
2007
Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in human U251 malignant glioma…
Loss of the PTEN tumor suppressor gene and amplification of the epidermal growth factor receptor (EGFR), which is common in… 
2000
2000
A Phase II Study of Nimustine Hydrochloride, Cisplatin, and Etoposide Combination Chemotherapy for Supratentorial Malignant Gliomas
Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial… 
1999
1999
Dacarbazine, Nimustine Hydrochloride, Cisplatin and Tamoxifen Combination Chemotherapy for Advanced Malignant Melanoma
Melanoma is an uncommon disease in Japan. The incidence, however, has been gradually increasing in the last two decades, as in… 
1990
1990
Thiol depletion and chemosensitization on nimustine hydrochloride by methionine-depleting total parenteral nutrition.
As an adjunct to cancer chemotherapy, we had succeeded in creating the methionine depletion in vivo, using the technique of total… 
1989
1989
Pathogenesis of persistent truncus arteriosus induced by nimustine hydrochloride in chick embryos.
Nimustine hydrochloride (ACNU) is a nitrosourea derivative anticancer agent which has been shown to cause persistent truncus… 
1987
1987
Randomized controlled study of the effect of adjuvant immunotherapy with Picibanil on 51 malignant gliomas.
1983
1983
In vitro studies on potentiation of cytotoxic effects of anticancer drugs by interferon on a human neoplastic cell line (HeLa).
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