Nifurtimox

Known as: 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide, 4-Thiomorpholinamine, 3-methyl-N-((5-nitro-2-furanyl)methylene)-, 1,1-dioxide, Nifurtimox [Chemical/Ingredient] 
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
0204019722017

Papers overview

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2011
2011
The prodrug nifurtimox has been used for more than 40 years to treat Chagas disease and forms part of a recently approved… (More)
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2010
2010
BACKGROUND Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce. We… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease… (More)
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Highly Cited
2008
Highly Cited
2008
Nifurtimox and benznidazole are the front-line drugs used to treat Chagas disease, the most important parasitic infection in the… (More)
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2007
2007
BACKGROUND Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for… (More)
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2000
2000
In the present work we show that acute infection of C3H mice with the CL strain of Trypanosoma cruzi is characterized by an… (More)
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1998
1998
Twenty-seven Trypanosoma cruzi strains, susceptible or naturally resistant to the nitroderivatives benznidazole and nifurtimox… (More)
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Highly Cited
1987
Highly Cited
1987
The susceptibility and natural resistance to two nitroheterocyclic derivatives used clinically in Chagas disease (nifurtimox and… (More)
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1985
1985
A test was made of the susceptibility of 30 strains of Trypanosoma cruzi to chemotherapy with nifurtimox (Bay 2502) and… (More)
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1981
1981
Nifurtimox is reduced by rat liver microsomes to a nitro anion-free radical as indicated by ESR spectroscopy. This subcellular… (More)
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