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Nifurtimox
Known as:
4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide
, 4-Thiomorpholinamine, 3-methyl-N-((5-nitro-2-furanyl)methylene)-, 1,1-dioxide
, Nifurtimox [Chemical/Ingredient]
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing…
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National Institutes of Health
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Related topics
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11 relations
Narrower (2)
Bayer 2502
Lampit
In Blood
NCIt Antineoplastic Agent Terminology
agonists
analogs & derivatives
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Broader (1)
Trypanocidal Agents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Gambiense sleeping sickness: re-emerging and soon untreatable?
S. V. Nieuwenhove
2000
Corpus ID: 1807298
Towards the end of the 1950s, sleeping sickness caused by Trypanosoma brucei gambiense was believed to be on the verge of…
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Highly Cited
1999
Highly Cited
1999
QUIMIOTERAPIA DE LA ENFERMEDAD DE CHAGAS
A. Stoppani
1999
Corpus ID: 201949521
1988
1988
[Chagas' disease: clastogenic effect of nifurtimox and benznidazole in children].
Moya Pr
,
Trombotto Gt
Medicina
1988
Corpus ID: 222257007
Les 2 medicaments produisent une elevation du pourcentage de micro-noyaux et une augmentation de la frequence de l'expression des…
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1988
1988
Changes in sleep and wakefulness following single and repeated exposures to toluene vapor in rats
H. Arito
,
H. Tsuruta
,
M. Oguri
Archives of Toxicology
1988
Corpus ID: 16871965
Male rats with indwelling electrodes for electroencephalographic (EEG), electromyographic (EMG) and electrooculographic (EOG…
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1987
1987
Species and sex differences in the liver microsomal nitroreductive biotransformation of nifurtimox and benznidazole.
E. Aguilar
,
C. Koldobsky
,
E. G. de Toranzo
,
J. Castro
Archives internationales de pharmacodynamie et de…
1987
Corpus ID: 24582608
Nifurtimox (NFX) and Benznidazole (Bz) are two drugs effective against acute Chagas' disease. Both have considerable toxic side…
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1985
1985
Benznidazole and nifurtimox nitroreductase activity in liver microsomes from male rats preinduced with phenobarbital or 3-methylcholanthrene.
Aguilar Eg
,
Desai Ck
,
D. Eg
,
Castro Ja
1985
Corpus ID: 88590912
Abstract Liver microsomes from Sprague-Dawley male rats are able to biotransform Benznidazole (Bz) or Nifurtimox (NFX) by…
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1984
1984
Studies on nifurtimox nitroreductase activity in liver and other rat tissues.
M. Masana
,
D. Eg
,
Castro Ja
Archives internationales de pharmacodynamie et de…
1984
Corpus ID: 8093457
Rat liver microsomes exhibit nifurtimox (NFX) nitroreductase activity, which is mostly NADPH-dependent and is completely…
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1983
1983
Nitroreduction of benznidazole and nifurtimox by rat and human feces.
D. Eg
,
M. Masana
,
J. A. Castro
Research communications in chemical pathology and…
1983
Corpus ID: 28105845
Rat and human feces are able to reduce nitro group from Benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) and Nifurtimox (4[5…
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1978
1978
Tissue-reacting antibodies (EVI antibodies) in nifurtimox-treated patients with Chagas's disease.
G. Schmuñis
,
P. Cossio
,
A. Szarfman
,
L. Coarasa
,
R. Arana
Journal of Infectious Diseases
1978
Corpus ID: 28649353
Antibodies reacting against endothelial cells, vascular structures, and heart and skeletal muscle cells (EVI antibodies) were…
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1977
1977
In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.
K. Kinnamon
,
E. Steck
,
W. Hanson
,
W. L. Chapman
Journal of Medicinal Chemistry
1977
Corpus ID: 9017207
Nine of 25 carefully selected compounds (from a stock of more than 200 000 chemical species amassed principally as a result of…
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