Neotrofin

Depression is one of the most common neuropsychiatric disorders and has been associated with a wide range of neuronal structural… (More)

Periventricular leukomalacia (PVL) is the dominant form of brain injury in premature infants and no specific treatment is… (More)

Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. Neotrofin, a neurotrophin agonist, has been shown to… (More)

We investigated the ability of Neotrofin, an agent that enhances endogenous nerve growth factor (NGF) levels, to prevent… (More)

There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has… (More)

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin… (More)

We report peripheral actions in rats of Neotrofin, a purine derivative of therapeutic interest. Systemic injections mimicked NGF… (More)

Neotrofin, a reported inducer of CNS neurotrophic factor synthesis and release, with memory-enhancing activity and demonstrated… (More)

PURPOSE Recent research on the purine derivative of hypoxanthine Neotrofin (4-[[3-(1,6-dihydro-6-oxo-9-purin-9-yl)-1-oxopropyl… (More)

Neotrofin (AIT-082; leteprinim potassium) is transported out of brain by a saturable mechanism and in this study the mechanisms… (More)