Neotrofin

Depression is one of the most common neuropsychiatric disorders and has been associated with a wide range of neuronal structural… Expand

Periventricular leukomalacia (PVL) is the dominant form of brain injury in premature infants and no specific treatment is… Expand

Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. Neotrofin, a neurotrophin agonist, has been shown to… Expand

We investigated the ability of Neotrofin, an agent that enhances endogenous nerve growth factor (NGF) levels, to prevent… Expand

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin… Expand

There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has… Expand

We report peripheral actions in rats of Neotrofin, a purine derivative of therapeutic interest. Systemic injections mimicked NGF… Expand

Neotrofin, a reported inducer of CNS neurotrophic factor synthesis and release, with memory-enhancing activity and demonstrated… Expand

PURPOSE Recent research on the purine derivative of hypoxanthine Neotrofin (4-[[3-(1,6-dihydro-6-oxo-9-purin-9-yl)-1-oxopropyl… Expand

A fundamental feature of any drug designed to treat a disease of the central nervous system is the ability to cross the blood… Expand