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Neotrofin
Â
National Institutes of Health
Topic mentions per year
Topic mentions per year
1999-2013
0
2
4
1999
2013
Papers overview
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2013
2013
Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat.
Junxia Luo
,
Lin Zhang
,
Nannan Ning
,
Hong Jiang
,
Shu-Yan Yu
Behavioural brain research
2013
Depression is one of the most common neuropsychiatric disorders and has been associated with a wide range of neuronal structural…Â
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2012
2012
Neuroprotective effect of neotrofin in a neonatal rat model of periventricular leukomalacia.
Funda Tüzün
,
Pınar Gençpınar
,
+5 authors
Abdullah Kumral
Neuroscience letters
2012
Periventricular leukomalacia (PVL) is the dominant form of brain injury in premature infants and no specific treatment is…Â
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2011
2011
Effects of neotrofin on neonatal hypoxic ischemic brain injury.
Pınar Gençpınar
,
Funda Tüzün
,
+4 authors
Abdullah Kumral
Neuroscience letters
2011
Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. Neotrofin, a neurotrophin agonist, has been shown to…Â
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2006
2006
Protection of sensory function in diabetic rats by Neotrofin.
Nigel A. Calcutt
,
Jason D Freshwater
,
Nils Hauptmann
,
Eve M. Taylor
,
Andrew P. Mizisin
European journal of pharmacology
2006
We investigated the ability of Neotrofin, an agent that enhances endogenous nerve growth factor (NGF) levels, to prevent…Â
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2003
2003
Neotrofin increases heme oxygenase-1 selectively in neurons.
Xiaojun Wang
,
Nils Hauptmann
,
Eve M. Taylor
,
Mark Foreman
,
Leslie A Khawli
,
Mahin. D. Maines
Brain research
2003
There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has…Â
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2003
2003
A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild Alzheimer's disease patients.
Michael J Grundman
,
Edmund Capparelli
,
+11 authors
Leon J. Thal
Life sciences
2003
A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin…Â
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2003
2003
Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin.
Michael V Holmes
,
Dusica Maysinger
,
Anne Foerster
,
Evi Pertens
,
Cia Barlas
,
Jack Diamond
Molecular and cellular neurosciences
2003
We report peripheral actions in rats of Neotrofin, a purine derivative of therapeutic interest. Systemic injections mimicked NGF…Â
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2002
2002
Brain metabolic effects of Neotrofin in patients with Alzheimer's disease.
Steven G. Potkin
,
Gustavo Alva
,
David B. Keator
,
Danilo Carreon
,
Kirsten Fleming
,
James H. Fallon
Brain research
2002
Neotrofin, a reported inducer of CNS neurotrophic factor synthesis and release, with memory-enhancing activity and demonstrated…Â
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2002
2002
The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats.
J J Garcia Ramirez
,
Tehnaz N Parakh
,
+4 authors
A Becton
Restorative neurology and neuroscience
2002
PURPOSE Recent research on the purine derivative of hypoxanthine Neotrofin (4-[[3-(1,6-dihydro-6-oxo-9-purin-9-yl)-1-oxopropyl…Â
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2002
2002
Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters.
Rongzi Yan
,
Eve M. Taylor
Drug metabolism and disposition: the biological…
2002
Neotrofin (AIT-082; leteprinim potassium) is transported out of brain by a saturable mechanism and in this study the mechanisms…Â
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