Neotrofin

Depression is one of the most common neuropsychiatric disorders and has been associated with a wide range of neuronal structural… Expand

Periventricular leukomalacia (PVL) is the dominant form of brain injury in premature infants and no specific treatment is… Expand

Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. Neotrofin, a neurotrophin agonist, has been shown to… Expand

We investigated the ability of Neotrofin, an agent that enhances endogenous nerve growth factor (NGF) levels, to prevent… Expand

Summary.The heme oxygenase isozymes, HO-1 and HO-2, oxidatively cleave the heme molecule to produce biliverdin and the gaseous… Expand

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin… Expand

There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has… Expand

Neotrofin, a reported inducer of CNS neurotrophic factor synthesis and release, with memory-enhancing activity and demonstrated… Expand

Neotrofin (AIT-082; leteprinim potassium) is transported out of brain by a saturable mechanism and in this study the mechanisms… Expand

PURPOSE Recent research on the purine derivative of hypoxanthine Neotrofin (4-[[3-(1,6-dihydro-6-oxo-9-purin-9-yl)-1-oxopropyl… Expand