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Neotrofin

National Institutes of Health

Papers overview

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2013
2013
Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat
2006
2006
Protection of sensory function in diabetic rats by Neotrofin.
2005
2005
Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response
Summary.The heme oxygenase isozymes, HO-1 and HO-2, oxidatively cleave the heme molecule to produce biliverdin and the gaseous… 
2003
2003
A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild Alzheimer's disease patients.
2003
2003
Neotrofin increases heme oxygenase-1 selectively in neurons
2002
2002
The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats.
PURPOSE Recent research on the purine derivative of hypoxanthine Neotrofin (4-[[3-(1,6-dihydro-6-oxo-9-purin-9-yl)-1-oxopropyl… 
2002
2002
Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters.
  • R. YanE. Taylor
  • Drug metabolism and disposition: the biological…
  • 2002
  • Corpus ID: 5786537
Neotrofin (AIT-082; leteprinim potassium) is transported out of brain by a saturable mechanism and in this study the mechanisms… 
2002
2002
Brain metabolic effects of Neotrofin in patients with Alzheimer’s disease
2000
2000
AIT-082, a cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism.
A fundamental feature of any drug designed to treat a disease of the central nervous system is the ability to cross the blood… 
1999
1999
AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury.
The synthetic purine 4-[[3-(1,6 dihydro-6-oxo-9-purin-9-yl)-1-oxypropyl] amino] benzoic acid (AIT-082, Neotrofin, leteprinim… 
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