Negative Regulation of Receptor Activation

Known as: Receptor Inactivation, Receptor Inhibition 
Any intercellular signaling process that reduces the frequency or extent of binding of a cognate ligand to an intracellular or transmembrane receptor… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
OBJECTIVES The phase III RADIATE study examined the efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To examine the efficacy and safety of the humanized anti-interleukin-6 receptor antibody tocilizumab combined with… (More)
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Highly Cited
2008
Highly Cited
2008
Fibrodysplasia ossificans progressiva (FOP) is a congenital disorder of progressive and widespread postnatal ossification of soft… (More)
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Highly Cited
2007
Highly Cited
2007
NMDA receptors mediate excitatory postsynaptic potentials throughout the brain but, paradoxically, NMDA receptor antagonists… (More)
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Highly Cited
2005
Highly Cited
2005
Treatment of second- and third-line patients with non-small-cell lung carcinoma (NSCLC) with the epidermal growth factor receptor… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVES We investigated whether patients who suffered subacute stent thrombosis (SAT) have higher post-treatment reactivity… (More)
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Highly Cited
2004
Highly Cited
2004
Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of this phenomenon has largely been… (More)
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Highly Cited
2002
Highly Cited
2002
Aripiprazole is the first next-generation atypical antipsychotic with a mechanism of action that differs from currently marketed… (More)
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Highly Cited
2002
Highly Cited
2002
This study was undertaken to demonstrate the unique specificity of the chemokine receptor CXCR4 antagonist AMD3100. Calcium flux… (More)
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Highly Cited
1982
Highly Cited
1982
In the guinea pig ileum myenteric plexus--longitudinal muscle preparation, dynorphin-(1--13) and the prototypical kappa agonist… (More)
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