NVP-BKM120

 
National Institutes of Health

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Topic mentions per year

2011-2017
02420112017

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2016
2016
NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as… (More)
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2015
2015
The multidrug resistance (MDR) phenotype often accompanies activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway… (More)
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2015
2015
OBJECTIVE To investigatethe effect of NVP-BKM120 on the triple-negative breast cancer cell lines. METHODS Breast cancer cell… (More)
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2014
2014
Constitutively active phosphoinositide 3-kinase (PI3K) signaling is a common feature of T-cell acute lymphoblastic leukemia (T… (More)
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2013
2013
The effects of class I PI3K inhibitor NVP-BKM120 on cell proliferation, cell cycle distribution, cellular apoptosis… (More)
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2013
2013
This study focuses on determining whether and how the novel PI3 kinase inhibitor NVP-BKM120 (BKM120) induces apoptosis and… (More)
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Highly Cited
2012
Highly Cited
2012
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional… (More)
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2012
2012
PURPOSE The aim of this study was to show preclinical efficacy and clinical development potential of NVP-BKM120, a selective pan… (More)
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2012
2012
INTRODUCTION We assessed expression of p85 and p110α PI3K subunits in non-small cell lung cancer (NSCLC) specimens and the… (More)
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2011
2011
Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide… (More)
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