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NUT Midline Carcinoma

Known as: Carcinoma with t(15;19)(q13;p13.1) Translocation, Midline Carcinoma of Children and Young Adults with NUT Rearrangement 
A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly… 
National Institutes of Health

Related topics

Related topics

12 relations
BRD4 geneBRD4 protein, humanBRD4 wt AlleleBRD4/C15orf55 Fusion Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Metastatic NUT Midline Carcinoma Treated With Aggressive Neoadjuvant Chemotherapy, Radiation, and Resection: A Case Report and Review of the Literature.
NUT midline carcinoma, characterized by the rearrangement of the nuclear protein in testis (NUTM1) gene, is a rare and aggressive… 
2020
2020
A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult
Author(s): Ko, Kyungmin; Kitani, Takashi; Harris, Brent T; Anaizi, Amjad N; Solomon, David; Perry, Arie; Toretsky, Jeffrey… 
2018
2018
Rediagnosis of Lung Cancer as NUT Midline Carcinoma Based on Clues From Tumor Genomic Profiling.
Tumor DNA sequencing can identify rare driver genomic alterations that suggest targets for cancer therapy, even when these… 
2018
2018
NUT Midline Carcinoma in the Mediastinum in a Ten-Year-Old Boy.
2017
2017
The Optimization of the Nuclear Protein in Testis (NUT) Antibody and its Importance and Impact in the Pathology Lab
Review
2016
Review
2016
Abstract 4693: Mechanism-based combination strategies for BET inhibitors in NUT midline carcinoma
NUT midline carcinoma (NMC) is a highly aggressive squamous cell cancer that responds poorly to standard chemotherapuetic… 
2015
2015
IDENTIFICATION OF POTENT BROMODOMAIN4 (BRD4) INHIBITORS BY ENERGY- PHARMACOPHORE BASED VIRTUAL SCREENING TO TARGET BRD4-NUT MIDLINE CARCINOMA
Objective: Protein-protein interactions (PPI’s) have been used as a target in various diseases. One such major role of PPI’s… 
2014
2014
A novel NUT translocation partner binds to BRD4 and is necessary for the blockade of differentiation in NUT midline carcinoma (59.8)
NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that typically harbors BRD4/3‐NUT fusion oncogenes… 
2013
2013
A case of NUT midline carcinoma with no HPV infection, slight EWSR1 rearrangement and strong expression of EGFR.
NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a… 
Review
2012
Review
2012
[Utility of NUT gene expression and rearrangement in diagnosis of NUT midline carcinoma in upper respiratory tract].
OBJECTIVE To investigate the importance of expression of the NUT gene and its rearrangement in diagnosing NUT midline carcinoma… 
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