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NU 7441

Known as: NU-7441, NU7441 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2017
0246820042017

Papers overview

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2015
2015
NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor
The current standard of care for lung cancer consists of concurrent chemotherapy and radiation. Several studies have shown that… (More)
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2013
2013
DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin
DNA-dependent protein kinase (DNA-PK) plays a key role in the repair of DNA double-strand breaks (DSBs) that are probably the… (More)
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2012
2012
DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor.
Radiation therapy (RT) is an effective strategy for the treatment of localized prostate cancer (PCa) as well as local invasion… (More)
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2011
2011
Targeting the DNA Double Strand Break Repair Machinery in Prostate Cancer
Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease… (More)
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2011
2011
Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
Inhibition of DNA repair is emerging as a new therapeutic strategy for cancer treatment. One promising target is DNA-PK, a… (More)
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2008
2008
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.
PURPOSE del(17p), del(11q), and associated p53 dysfunction predict for short survival and chemoresistance in B-cell chronic… (More)
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2008
2008
Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin.
The chemotherapeutic drugs cisplatin and oxaliplatin act by induction of DNA damage, including monoadducts, intrastrand and… (More)
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Highly Cited
2006
Highly Cited
2006
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by ionizing radiation and topoisomerase II poisons, such as… (More)
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2006
2006
UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.
Signaling from arrested replication forks plays a role in maintaining genome stability. We have investigated this process in… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted… (More)
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