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NU 7441

Known as: NU-7441, NU7441 
National Institutes of Health

Papers overview

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2016
2016
Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells
Malignant osteosarcoma (OS) is still a deadly disease for many affected patients. The search for the novel anti-OS agent is… 
2016
2016
Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells.
Here, we compared the effects of inhibitors of three phosphatidylinositol-3-kinase-related kinases, ATM, ATR a DNA-PK, on… 
2015
2015
DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600.
2015
2015
Changes in the response of MCF-7 cells to ionizing radiation after the combination of ATM and DNA-PK inhibition
The aim of the present study is to evaluate the role of ATM (KU55933) and DNA-PK (NU7441) inhibitors in the repair of double… 
2015
2015
NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor
The current standard of care for lung cancer consists of concurrent chemotherapy and radiation. Several studies have shown that… 
2014
2014
Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening
MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC… 
2013
2013
DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose.
PURPOSE The goal of this study was to determine whether Compound 49b stimulates insulin-like growth factor binding protein-3… 
2013
2013
Abstract 5459: Molecular mechanisms of dysregulated GLI activation in Hedgehog (HH)-dependent survival in human colon cancer.
In normal cellular processes the canonical Hedgehog (HH) pathway signals via the transmembrane receptor PTCH, intermediary… 
2012
2012
292 Evolution of Highly Selective HSP90a/β Inhibitors with Unique Binding Mode
2011
2011
DNA-Dependent Protein Kinase and Ataxia Telangiectasia Mutated (ATM) Promote Cell Survival in Response to NK314, a Topoisomerase IIα Inhibitor
4-Hydroxy-5-methoxy-2,3-dihydro-1H-[1,3]benzodioxolo[5,6-c]pyrrolo[1,2-f]-phenanthridium chloride (NK314) is a benzo[c… 
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