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NU 7441

Known as: NU-7441, NU7441 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BackgroundThe ability to modify the genome of any cell at a precise location has drastically improved with the recent discovery… Expand
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Highly Cited
2013
Highly Cited
2013
Synthetic lethality is a genetic concept in which cell death is induced by the combination of mutations in two sensitive genes… Expand
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Highly Cited
2013
Highly Cited
2013
Exposure to genotoxic agents, such as irradiation produces DNA damage, the toxicity of which is augmented when the DNA repair is… Expand
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Highly Cited
2013
Highly Cited
2013
DNA-dependent protein kinase (DNA-PK) plays a key role in the repair of DNA double-strand breaks (DSBs) that are probably the… Expand
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Highly Cited
2011
Highly Cited
2011
PurposeInhibition of DNA repair is emerging as a new therapeutic strategy for cancer treatment. One promising target is DNA-PK, a… Expand
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Highly Cited
2011
Highly Cited
2011
Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: del(17p), del(11q), and associated p53 dysfunction predict for short survival and chemoresistance in B-cell chronic… Expand
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Highly Cited
2006
Highly Cited
2006
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by ionizing radiation and topoisomerase II poisons, such as… Expand
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Highly Cited
2005
Highly Cited
2005
Structure-activity relationships for inhibition of DNA-dependent protein kinase (DNA-PK) have been defined for substituted… Expand
Highly Cited
2004
Highly Cited
2004
A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted… Expand