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NS 1643

Known as: NS-1643, NS1643 
National Institutes of Health

Papers overview

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2017
2017
CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived…
2014
2014
Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators
One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent… 
2012
2012
Structure-Guided Topographic Mapping and Mutagenesis to Elucidate Binding Sites for the Human Ether-a-Go-Go-Related Gene 1 Potassium Channel (KCNH2) Activator NS1643
Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1… 
2012
2012
Effects of the Small Molecule HERG Activator NS1643 on Kv11.3 Channels
NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents… 
2011
2011
Molecular Determinants of Human ether-à-go-go-Related Gene 1 (hERG1) K+ Channel Activation by NS1643
Human ether-à-go-go-related gene 1 (hERG1) channels conduct the rapid delayed rectifier K+ current, IKr, an important determinant… 
2011
2011
Strong Activation of ether-à-go-go-Related Gene 1 K+ Channel Isoforms by NS1643 in Human Embryonic Kidney 293 and Chinese Hamster Ovary Cells
Two different mechanisms leading to increased current have been described for the small-molecule human ether-à-go-go-related gene… 
2010
2010
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
BACKGROUND AND PURPOSE Kv11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart… 
2008
2008
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
AIMS Impaired repolarization in cardiac myocytes can lead to long QT syndrome (LQTS), with delayed repolarization and increased… 
2008
2008
Potent Activation of Large-Conductance Ca2+-Activated K+ Channels by the Diphenylurea 1,3-Bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in Pituitary Tumor (GH3) Cells
1,3-Bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) is reported to be an activator of human ether-à-go-go-related gene… 
2007
2007
Activation of ERG2 potassium channels by the diphenylurea NS1643
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