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NS 1643

Known as: NS-1643, NS1643 
National Institutes of Health

Papers overview

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2019
2019
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential… 
2017
2017
CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived…
2016
2016
hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism
The function of Kv11.1 is emerging in breast cancer biology, as a growing body of evidence indicates that the hERG1/Kv11.1… 
Highly Cited
2013
Highly Cited
2013
A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
Highly Cited
2013
Highly Cited
2013
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program
Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian… 
2012
2012
Structure-Guided Topographic Mapping and Mutagenesis to Elucidate Binding Sites for the Human Ether-a-Go-Go-Related Gene 1 Potassium Channel (KCNH2) Activator NS1643
Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1… 
2008
2008
Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl…
We studied the mechanisms and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino… 
2008
2008
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
AIMS Impaired repolarization in cardiac myocytes can lead to long QT syndrome (LQTS), with delayed repolarization and increased… 
Highly Cited
2006
Highly Cited
2006
Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of… 
Highly Cited
2006
Highly Cited
2006
Mechanism of Action of a Novel Human ether-a-go-go-Related Gene Channel Activator
1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator of human ether-a-go-go-related gene… 
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