NS 1643

Known as: NS-1643, NS1643 
 
National Institutes of Health

Papers overview

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2016
2016
The function of Kv11.1 is emerging in breast cancer biology, as a growing body of evidence indicates that the hERG1/Kv11.1… (More)
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2015
2015
Activators of hERG1 such as NS1643 are being developed for congenital/acquired long QT syndrome. Previous studies identify the… (More)
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2014
2014
One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent… (More)
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2013
2013
INTRODUCTION In the present study, we investigated whether a new biomarker - index of cardiac electrophysiological balance (iCEB… (More)
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2013
2013
Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian… (More)
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2012
2012
Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1… (More)
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2011
2011
Human ether-à-go-go-related gene 1 (hERG1) channels conduct the rapid delayed rectifier K+ current, I(Kr), an important… (More)
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2011
2011
Transgenic rabbits expressing pore mutants of K(V)7.1 display a long QT syndrome 1 (LQT1) phenotype. Recently, NS1643 has been… (More)
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2010
2010
BACKGROUND AND PURPOSE K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain… (More)
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2008
2008
We studied the mechanisms and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino… (More)
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