NS 1643

Known as: NS-1643, NS1643 
 
National Institutes of Health

Papers overview

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2016
2016
hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism
The function of Kv11.1 is emerging in breast cancer biology, as a growing body of evidence indicates that the hERG1/Kv11.1… (More)
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2015
2015
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Activators of hERG1 such as NS1643 are being developed for congenital/acquired long QT syndrome. Previous studies identify the… (More)
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2014
2014
Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators
One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent… (More)
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2013
2013
A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
INTRODUCTION In the present study, we investigated whether a new biomarker - index of cardiac electrophysiological balance (iCEB… (More)
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2013
2013
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program
Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian… (More)
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2012
2012
Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.
Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1… (More)
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2011
2011
Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.
Human ether-à-go-go-related gene 1 (hERG1) channels conduct the rapid delayed rectifier K+ current, I(Kr), an important… (More)
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2011
2011
Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits.
Transgenic rabbits expressing pore mutants of K(V)7.1 display a long QT syndrome 1 (LQT1) phenotype. Recently, NS1643 has been… (More)
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2010
2010
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels.
BACKGROUND AND PURPOSE K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain… (More)
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2008
2008
Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl…
We studied the mechanisms and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino… (More)
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