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NS 1643

Known as: NS-1643, NS1643 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential… 
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2017
2017
CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived…
INTRODUCTION The use of multi-electrode arrays (MEA) in combination with human induced pluripotent stem cell-derived… 
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2015
2015
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Activators of hERG1 such as NS1643 are being developed for congenital/acquired long QT syndrome. Previous studies identify the… 
Highly Cited
2013
Highly Cited
2013
A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
INTRODUCTION In the present study, we investigated whether a new biomarker - index of cardiac electrophysiological balance (iCEB… 
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2013
2013
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program
Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian… 
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2012
2012
Structure-Guided Topographic Mapping and Mutagenesis to Elucidate Binding Sites for the Human Ether-a-Go-Go-Related Gene 1 Potassium Channel (KCNH2) Activator NS1643
Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1… 
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2008
2008
Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl…
We studied the mechanisms and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino… 
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2008
2008
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
AIMS Impaired repolarization in cardiac myocytes can lead to long QT syndrome (LQTS), with delayed repolarization and increased… 
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Highly Cited
2006
Highly Cited
2006
Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of… 
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Highly Cited
2006
Highly Cited
2006
Mechanism of Action of a Novel Human ether-a-go-go-Related Gene Channel Activator
1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator of human ether-a-go-go-related gene… 
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