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NS 1643
Known as:
NS-1643
, NS1643
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
Eun-Kyoung Breuer
,
Daniela F. Fukushiro-Lopes
,
+12 authors
S. Gentile
Cell Death and Disease
2019
Corpus ID: 67788246
Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential…
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2017
2017
CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived…
Takashi Kitaguchi
,
Y. Moriyama
,
+14 authors
N. Miyamoto
Journal of pharmacological and toxicological…
2017
Corpus ID: 205608739
2016
2016
hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism
Mathew Perez-Neut
,
V. Rao
,
S. Gentile
OncoTarget
2016
Corpus ID: 4536904
The function of Kv11.1 is emerging in breast cancer biology, as a growing body of evidence indicates that the hERG1/Kv11.1…
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Highly Cited
2013
Highly Cited
2013
A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
Hua-rong Lu
,
G. Yan
,
D. Gallacher
Journal of pharmacological and toxicological…
2013
Corpus ID: 4728982
Highly Cited
2013
Highly Cited
2013
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program
K. Lansu
,
S. Gentile
Cell Death and Disease
2013
Corpus ID: 1355538
Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian…
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2012
2012
Structure-Guided Topographic Mapping and Mutagenesis to Elucidate Binding Sites for the Human Ether-a-Go-Go-Related Gene 1 Potassium Channel (KCNH2) Activator NS1643
S. Durdağı
,
Jiqing Guo
,
J. Lees-Miller
,
S. Noskov
,
H. Duff
Journal of Pharmacology and Experimental…
2012
Corpus ID: 12480370
Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1…
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2008
2008
Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl…
Xulin Xu
,
M. Recanatini
,
M. Roberti
,
G. Tseng
Molecular Pharmacology
2008
Corpus ID: 206503276
We studied the mechanisms and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino…
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2008
2008
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
T. G. Diness
,
Yung-Hsin Yeh
,
+6 authors
S. Nattel
Cardiovascular Research
2008
Corpus ID: 27038014
AIMS Impaired repolarization in cardiac myocytes can lead to long QT syndrome (LQTS), with delayed repolarization and increased…
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Highly Cited
2006
Highly Cited
2006
Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
R. S. Hansen
,
T. G. Diness
,
+4 authors
M. Grunnet
Molecular Pharmacology
2006
Corpus ID: 5779342
The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of…
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Highly Cited
2006
Highly Cited
2006
Mechanism of Action of a Novel Human ether-a-go-go-Related Gene Channel Activator
Ó. Casis
,
S. Olesen
,
M. Sanguinetti
Molecular Pharmacology
2006
Corpus ID: 14998433
1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator of human ether-a-go-go-related gene…
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