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NR1I2 protein, human

Known as: Steroid and Xenobiotic Receptor, nuclear receptor subfamily 1, group I, member 2 protein, human, Pregnane X Nuclear Receptor 
Nuclear receptor subfamily 1 group I member 2 (434 aa, ~50 kDa) is encoded by the human NR1I2 gene. This protein is involved in the metabolism of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Background: Bisphenol A (BPA) is a base chemical used extensively in many consumer products. BPA and its analogues are present in… Expand
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Highly Cited
2011
Highly Cited
2011
Background Adipocytes from mesenteric white adipose tissue amplify the inflammatory response and participate in inflammation… Expand
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Highly Cited
2010
Highly Cited
2010
Human pregnane X receptor (PXR) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Rifaximin, a human… Expand
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Highly Cited
2007
Highly Cited
2007
Cafestol, a diterpene present in unfiltered coffee brews such as Scandinavian boiled, Turkish, and cafetière coffee, is the most… Expand
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Highly Cited
2006
Highly Cited
2006
The ATP-driven drug export pump, P-glycoprotein, is a primary gatekeeper of the blood-brain barrier and a major impediment to… Expand
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Highly Cited
2001
Highly Cited
2001
Hepatic hydroxylation is an essential step in the metabolism and excretion of bile acids and is necessary to avoid pathologic… Expand
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Highly Cited
2000
Highly Cited
2000
Recently, Pregnane X receptor (PXR), a new member of the nuclear receptor superfamily, was shown to mediate the effects of… Expand
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Highly Cited
2000
Highly Cited
2000
The cytochrome CYP3A gene products, expressed in mammalian liver, are essential for the metabolism of lipophilic substrates… Expand
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Highly Cited
1998
Highly Cited
1998
The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics… Expand
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Highly Cited
1998
Highly Cited
1998
An important requirement for physiologic homeostasis is the detoxification and removal of endogenous hormones and xenobiotic… Expand
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