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NR1I2 protein, human

Known as: Steroid and Xenobiotic Receptor, nuclear receptor subfamily 1, group I, member 2 protein, human, Pregnane X Nuclear Receptor 
Nuclear receptor subfamily 1 group I member 2 (434 aa, ~50 kDa) is encoded by the human NR1I2 gene. This protein is involved in the metabolism of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Background: Bisphenol A (BPA) is a base chemical used extensively in many consumer products. BPA and its analogues are present in… Expand
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Review
2005
Review
2005
The oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and trofosfamide represent an important group of… Expand
Highly Cited
2005
Highly Cited
2005
The human nuclear xenobiotic receptor, pregnane X receptor (PXR), detects a variety of structurally distinct endogenous and… Expand
Highly Cited
2003
Highly Cited
2003
The pregnane X receptor (PXR) detects the presence of a wide variety of endogenous and xenobiotic compounds, and is a master… Expand
Highly Cited
2002
Highly Cited
2002
The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic… Expand
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Highly Cited
2001
Highly Cited
2001
Hepatic hydroxylation is an essential step in the metabolism and excretion of bile acids and is necessary to avoid pathologic… Expand
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Highly Cited
2000
Highly Cited
2000
The cytochrome CYP3A gene products, expressed in mammalian liver, are essential for the metabolism of lipophilic substrates… Expand
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Highly Cited
2000
Highly Cited
2000
Recently, Pregnane X receptor (PXR), a new member of the nuclear receptor superfamily, was shown to mediate the effects of… Expand
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Highly Cited
1998
Highly Cited
1998
The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics… Expand
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Highly Cited
1998
Highly Cited
1998
An important requirement for physiologic homeostasis is the detoxification and removal of endogenous hormones and xenobiotic… Expand
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