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NR1I2 protein, human

Known as: Steroid and Xenobiotic Receptor, nuclear receptor subfamily 1, group I, member 2 protein, human, Pregnane X Nuclear Receptor 
Nuclear receptor subfamily 1 group I member 2 (434 aa, ~50 kDa) is encoded by the human NR1I2 gene. This protein is involved in the metabolism of… 
National Institutes of Health

Related topics

Related topics

25 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation

Broader (1)

pregnane X receptor

Papers overview

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2018
2018
The pregnane X receptor ( PXR ) and the nuclear receptor corepressor 2 ( NCoR 2 ) modulate cell growth in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide. The pregnane X receptor (PXR) is a… 
2017
2017
Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor
Unintentional activation of xenosensing nuclear receptors pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR… 
2014
2014
Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism
Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent… 
2010
2010
Isolation and structure elucidation of novel acylated pregnane glycosides from Caralluma tuberculata against human breast cancer cells MCF-7 cells
2009
2009
The aldo-keto reductase Akr 1 b 7 gene is a common transcriptional target of xenobiotic receptors PXR and
AKR1B7 (aldo-keto reductase family 1, member 7), a member of the AKR superfamily, has been suggested to play an important role in… 
2006
2006
Involvement of nuclear receptors peroxisome proliferator -activated receptor alpha (PPAR alpha) and pregnane X receptor (PXR) in expressional regulation of organic cation/carnitine transporter OCTN2…
2005
2005
Regulation of ABCA1 in hepatocytes by the nuclear receptor PXR
Nuclear receptors that work as heterodimers with RXR control several aspects of lipid metabolism. One such nuclear receptor… 
2003
2003
Accelerated Communication INDUCTION OF CYTOCHROME P 450 3 A BY PACLITAXEL IN MICE : PIVOTAL ROLE OF THE NUCLEAR XENOBIOTIC RECEPTOR , PREGNANE X RECEPTOR
Paclitaxel, a taxane anti-microtubule agent, is known to induce CYP3A in rat and human hepatocytes. Recent studies suggest that a… 
2003
2003
Quantitation of CYP2B6, constitutive androstane receptor, and pregnane X receptor mRNA levels.
We read with great interest, an article in the January 2003 issue of Drug Metabolism and Disposition by [Chang et al. (2003)][1… 
1966
1966
Conformation of the 17-beta side chain of C-20 oxygenated pregnane derivatives as determined by nuclear magnetic resonance coupling CONSTANTS.