NR1H4 gene

Known as: FXR, RETINOID X RECEPTOR-INTERACTING PROTEIN 14, HRR1 
This gene is involved in bile acid binding and metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
05010019952017

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND & AIMS Obeticholic acid (OCA; INT-747, 6α-ethyl-chenodeoxycholic acid) is a semisynthetic derivative of the primary… (More)
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Highly Cited
2007
Highly Cited
2007
Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR… (More)
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Highly Cited
2007
Highly Cited
2007
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice lacking expression of FXR… (More)
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Highly Cited
2006
Highly Cited
2006
Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that… (More)
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Highly Cited
2006
Highly Cited
2006
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the… (More)
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Highly Cited
2006
Highly Cited
2006
The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a major role in the regulation of BA and… (More)
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Highly Cited
2004
Highly Cited
2004
We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal… (More)
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Highly Cited
2002
Highly Cited
2002
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
2002
Highly Cited
2002
The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the… (More)
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Highly Cited
1999
Highly Cited
1999
Intestinal bile acid-binding protein (I-BABP) is a cytosolic protein that binds bile acids (BAs) with a high affinity. In the… (More)
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