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NR0B2 gene

Known as: NR0B2, SHP1, NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2 
This gene is involved in transcriptional regulation and can stimulate transcriptional repression.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Bile salts play crucial roles in allowing the gastrointestinal system to digest, transport and metabolize nutrients. They… Expand
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Highly Cited
2012
Highly Cited
2012
The nuclear receptor farnesoid X receptor (FXR) acts as a liver protector by regulating normal liver homeostasis. Spontaneously… Expand
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Highly Cited
2011
Highly Cited
2011
Metformin is an oral anti-diabetic drug of the biguanide class that is commonly used to treat type 2 diabetes mellitus. This… Expand
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Highly Cited
2010
Highly Cited
2010
Pregnancy alters bile acid homeostasis and can unmask cholestatic disease in genetically predisposed but otherwise asymptomatic… Expand
Highly Cited
2009
Highly Cited
2009
The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR−/−) or… Expand
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Highly Cited
2007
Highly Cited
2007
Bile acid–binding resins, such as cholestyramine and colestimide, have been clinically used as cholesterol-lowering agents. These… Expand
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Highly Cited
2006
Highly Cited
2006
Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the… Expand
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Highly Cited
2005
Highly Cited
2005
SHP (small heterodimer partner) is an important component of the feedback regulatory cascade, which controls the conversion of… Expand
Highly Cited
2005
Highly Cited
2005
We have generated a line of mutant mouse that lacks betaKlotho, a protein that structurally resembles Klotho. The synthesis and… Expand
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Highly Cited
2003
Highly Cited
2003
The orphan nuclear hormone receptor SHP (gene designation NROB2) is an important component of a negative regulatory cascade by… Expand
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