NOTCH3 protein, human

Known as: Notch homolog 3 (Drosophila) protein, human, Neurogenic Locus Notch Homolog Protein 3, NOTCH3 
Neurogenic locus notch homolog protein 3 (2321 aa, ~244 kDa) is encoded by the human NOTCH3 gene. This protein plays a role in both cell fate… (More)
National Institutes of Health

Related topics

Related topics

15 relations
Ankyrin RepeatCell Fate ControlCellular MembraneEGF-Like Domain
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Broader (1)

Receptor, Notch3

Papers overview

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Highly Cited
2009
Highly Cited
2009
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common… (More)
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Highly Cited
2009
Highly Cited
2009
MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation.
MicroRNAs contribute to cancer development by acting as oncogenes or tumor suppressor genes. However, only a few microRNA target… (More)
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Highly Cited
2007
Highly Cited
2007
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.
Notch receptors are key regulators of development by controlling cell-fate determination in many multicellular organisms. Genes… (More)
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Highly Cited
2006
Highly Cited
2006
Notch3 gene amplification in ovarian cancer.
Gene amplification is one of the common mechanisms that activate oncogenes. In this study, we used single nucleotide polymorphism… (More)
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Highly Cited
2005
Highly Cited
2005
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… (More)
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Highly Cited
2004
Highly Cited
2004
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells.
Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate… (More)
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Highly Cited
2001
Highly Cited
2001
Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate
Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct… (More)
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Highly Cited
2000
Highly Cited
2000
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients.
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in… (More)
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Highly Cited
2000
Highly Cited
2000
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.
The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is… (More)
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Highly Cited
1997
Highly Cited
1997
Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients.
BACKGROUND CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy) is commonly… (More)
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