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NOTCH3 protein, human

Known as: Notch homolog 3 (Drosophila) protein, human, Neurogenic Locus Notch Homolog Protein 3, NOTCH3 
Neurogenic locus notch homolog protein 3 (2321 aa, ~244 kDa) is encoded by the human NOTCH3 gene. This protein plays a role in both cell fate… 
National Institutes of Health

Related topics

Related topics

15 relations
Ankyrin RepeatCell Fate ControlCellular MembraneEGF-Like Domain

Broader (1)

Receptor, Notch3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
mTORC1 Is Involved in Hypoxia‐Induced Pulmonary Hypertension Through the Activation of Notch3
Hypoxia‐induced pulmonary hypertension (HPH) is a clinical syndrome associated with high morbidity and mortality. However, the… 
2012
2012
Overexpression of Angiopoietin-1 Increases CD133+/c-kit+ Cells and Reduces Myocardial Apoptosis in db/db Mouse Infarcted Hearts
Hematopoietic progenitor CD133+/c-kit+ cells have been shown to be involved in myocardial healing following myocardial infarction… 
2011
2011
CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a hereditary… 
Highly Cited
2010
Highly Cited
2010
Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma.
Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is… 
2009
2009
Hes1 Potentiates T Cell Lymphomagenesis by Up-Regulating a Subset of Notch Target Genes
Background Hairy/Enhancer of Split (Hes) proteins are targets of the Notch signaling pathway and make up a class of basic helix… 
2009
2009
Notch3 and pTalpha/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.
Dysregulated generation and/or function of naturally occurring 'CD4(+)CD25(+) regulatory T cells' (T(reg)s) play key role in the… 
Highly Cited
2006
Highly Cited
2006
Effects of Delta1 and Jagged1 on Early Human Hematopoiesis: Correlation with Expression of Notch Signaling‐Related Genes in CD34+ Cells
It has been shown that Notch signaling mediated by ligands of both Jagged and Delta families expands the hematopoietic stem cell… 
Highly Cited
2003
Highly Cited
2003
Active Form of Notch Members Can Enforce T Lymphopoiesis on Lymphoid Progenitors in the Monolayer Culture Specific for B Cell Development1
The in vitro induction of T lymphopoiesis needs the precise stereoscopic structure of thymus tissues as seen in fetal thymus… 
Review
2000
Review
2000
Hereditary Vascular Dementia Linked to Notch 3 Mutations: CADASIL in British Families
Abstract: The most common form of familial vascular dementia is considered to be CADASIL or cerebral autosomal dominant… 
Review
2000
Review
2000
CADASIL: Hereditary Arteriopathy Leading to Multiple Brain Infarcts and Dementia
Abstract: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) often begins with… 
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