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NMNAT2 gene

Known as: PYRIDINE NUCLEOTIDE ADENYLYLTRANSFERASE 2, KIAA0479, PNAT2 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1… 
Highly Cited
2016
Highly Cited
2016
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of… 
Highly Cited
2015
Highly Cited
2015
Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
Highly Cited
2013
Highly Cited
2013
Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2
NMNAT2 is an NAD+-synthesizing enzyme with an essential axon maintenance role in primary culture neurons. We have generated an… 
Highly Cited
2013
Highly Cited
2013
Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2
Modulation of the subcellular localization of the endogenous axon survival factor Nmnat2 boosts its axon protective capacity… 
Highly Cited
2012
Highly Cited
2012
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.
Tauopathies, characterized by neurofibrillary tangles (NFTs) of phosphorylated tau proteins, are a group of neurodegenerative… 
Highly Cited
2012
Highly Cited
2012
Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo
Using transposon-mediated gene-trap mutagenesis, we have generated a novel mouse mutant termed Blad (Bloated Bladder). Homozygous… 
Highly Cited
2012
Highly Cited
2012
Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6
Highly Cited
2010
Highly Cited
2010
Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons
We conclude that endogenous Nmnat2 prevents spontaneous degeneration of healthy axons and propose that, when present, the more… 
Highly Cited
2010
Highly Cited
2010
Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2*
Nicotinamide mononucleotide (NMN) adenylyltransferase 2 (Nmnat2) catalyzes the synthesis of NAD from NMN and ATP. The Nmnat2… 
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