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NMNAT2 gene
Known as:
PYRIDINE NUCLEOTIDE ADENYLYLTRANSFERASE 2
, KIAA0479
, PNAT2
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
Lauren J Walker
,
Daniel W. Summers
,
Y. Sasaki
,
E. Brace
,
J. Milbrandt
,
A. Diantonio
eLife
2017
Corpus ID: 17714277
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1…
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Highly Cited
2016
Highly Cited
2016
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
Y. Ali
,
Hunter M Allen
,
+12 authors
Hui-Chen Lu
PLoS biology
2016
Corpus ID: 11344245
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of…
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Highly Cited
2015
Highly Cited
2015
Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
J. Gilley
,
G. Orsomando
,
I. Nascimento-Ferreira
,
M. Coleman
Cell reports
2015
Corpus ID: 16058822
Highly Cited
2013
Highly Cited
2013
Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2
J. Gilley
,
R. Adalbert
,
Gang Yu
,
M. Coleman
The Journal of Neuroscience
2013
Corpus ID: 6457725
NMNAT2 is an NAD+-synthesizing enzyme with an essential axon maintenance role in primary culture neurons. We have generated an…
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Highly Cited
2013
Highly Cited
2013
Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2
S. Milde
,
J. Gilley
,
M. Coleman
PLoS biology
2013
Corpus ID: 1037343
Modulation of the subcellular localization of the endogenous axon survival factor Nmnat2 boosts its axon protective capacity…
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Highly Cited
2012
Highly Cited
2012
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.
M. Ljungberg
,
Y. Ali
,
+4 authors
Hui-Chen Lu
Human molecular genetics
2012
Corpus ID: 14669515
Tauopathies, characterized by neurofibrillary tangles (NFTs) of phosphorylated tau proteins, are a group of neurodegenerative…
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Highly Cited
2012
Highly Cited
2012
Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo
Amy N. Hicks
,
D. Lorenzetti
,
+6 authors
C. Bishop
PloS one
2012
Corpus ID: 595599
Using transposon-mediated gene-trap mutagenesis, we have generated a novel mouse mutant termed Blad (Bloated Bladder). Homozygous…
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Highly Cited
2012
Highly Cited
2012
Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6
Y. Cai
,
Shan-shan Yu
,
+5 authors
Peiqing Liu
FEBS letters
2012
Corpus ID: 38260563
Highly Cited
2010
Highly Cited
2010
Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons
J. Gilley
,
M. Coleman
PLoS biology
2010
Corpus ID: 6041978
We conclude that endogenous Nmnat2 prevents spontaneous degeneration of healthy axons and propose that, when present, the more…
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Highly Cited
2010
Highly Cited
2010
Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2*
Paul R. Mayer
,
Nian Huang
,
Colleen M. Dewey
,
Daniel R. Dries
,
Hong Zhang
,
Gang Yu
The Journal of Biological Chemistry
2010
Corpus ID: 205305711
Nicotinamide mononucleotide (NMN) adenylyltransferase 2 (Nmnat2) catalyzes the synthesis of NAD from NMN and ATP. The Nmnat2…
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