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NLRP1 wt Allele

Known as: NLR Family, Pyrin Domain Containing 1 wt Allele, SLEV1, CARD7 
Human NLRP1 wild-type allele is located in the vicinity of 17p13.2 and is approximately 120 kb in length. This allele, which encodes NACHT, LRR and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Inflammation is a protective attempt by the host to remove injurious stimuli and initiate the tissue healing process. The… Expand
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Highly Cited
2009
Highly Cited
2009
Variants in the gene encoding NACHT leucine-rich-repeat protein 1 (NALP1), an important molecule in innate immunity, have… Expand
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Highly Cited
2008
Highly Cited
2008
NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that was suggested to promote… Expand
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Highly Cited
2008
Highly Cited
2008
Vigorous immune responses are induced in the immune privileged CNS by injury and disease, but the molecular mechanisms regulating… Expand
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Highly Cited
2007
Highly Cited
2007
Interleukin (IL)-1beta maturation is accomplished by caspase-1-mediated proteolysis, an essential element of innate immunity… Expand
Highly Cited
2007
Highly Cited
2007
BACKGROUND Autoimmune and autoinflammatory diseases involve interactions between genetic risk factors and environmental triggers… Expand
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Highly Cited
2007
Highly Cited
2007
Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by mutations in the NALP3/cryopyrin gene… Expand
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Highly Cited
2007
Highly Cited
2007
Caspases are intracellular proteases that cleave substrates involved in apoptosis or inflammation. In C. elegans, a paradigm for… Expand
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Highly Cited
2007
Highly Cited
2007
Generalized vitiligo is a common, multifactorial, polygenic disease in which autoimmune loss of melanocytes results in… Expand
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Highly Cited
2001
Highly Cited
2001
We report the deduced amino acid sequences of two alternately spliced isoforms, designated DEFCAP-L and -S, that differ in 44… Expand
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