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NEK9 protein, human

Known as: Nercc1 protein, human, Serine/Threonine-Protein Kinase Nek9, Nek8 
Serine/threonine-protein kinase Nek9 (979 aa, ~107 kDa) is encoded by the human NEK9 gene. This protein is involved in the progression of mitosis and… 
National Institutes of Health

Related topics

Related topics

12 relations
Casein Kinase I Isoform Delta, humanCell Cycle ProgressionChromosome SegregationEnzyme Gene

Broader (1)

NIMA-Related Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most… 
Highly Cited
2013
Highly Cited
2013
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.
Highly Cited
2013
Highly Cited
2013
Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression.
Mutations affecting the integrity and function of cilia have been identified in various genes over the last decade accounting for… 
Review
2012
Review
2012
Cell cycle regulation by the NEK family of protein kinases
Summary Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of… 
Highly Cited
2010
Highly Cited
2010
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy
Background Nephronophthisis associated ciliopathies (NPHP-AC) comprise a group of autosomal recessive cystic kidney diseases that… 
Highly Cited
2008
Highly Cited
2008
NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.
Nephronophthisis, an autosomal recessive kidney disease, is the most frequent genetic cause of chronic renal failure in the first… 
Highly Cited
2008
Highly Cited
2008
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
Nek8 is a serine/threonine kinase that is mutated in the jck (juvenile cystic kidneys) mouse, a model of autosomal recessive… 
Review
2005
Review
2005
Caught Nek-ing: cilia and centrioles
The Nek family of cell-cycle kinases is widely represented in eukaryotes and includes numerous proteins that were described only… 
Highly Cited
2004
Highly Cited
2004
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.
Highly Cited
2004
Highly Cited
2004
A NIMA-related kinase, Fa2p, localizes to a novel site in the proximal cilia of Chlamydomonas and mouse kidney cells.
Polycystic kidney disease and related syndromes involve dysregulation of cell proliferation in conjunction with ciliary defects… 
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