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NEK9 protein, human

Known as: Nercc1 protein, human, Serine/Threonine-Protein Kinase Nek9, Nek8 
Serine/threonine-protein kinase Nek9 (979 aa, ~107 kDa) is encoded by the human NEK9 gene. This protein is involved in the progression of mitosis and… Expand
National Institutes of Health

Related topics

Related topics

12 relations
Casein Kinase I Isoform Delta, humanCell Cycle ProgressionChromosome SegregationEnzyme Gene
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Broader (1)

NIMA-Related Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most… Expand
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Highly Cited
2013
Highly Cited
2013
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.
Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. NEK8/NPHP9 is a ciliary… Expand
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Review
2012
Review
2012
Cell cycle regulation by the NEK family of protein kinases
Summary Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of… Expand
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Highly Cited
2010
Highly Cited
2010
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy
Background Nephronophthisis associated ciliopathies (NPHP-AC) comprise a group of autosomal recessive cystic kidney diseases that… Expand
Highly Cited
2008
Highly Cited
2008
NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.
Nephronophthisis, an autosomal recessive kidney disease, is the most frequent genetic cause of chronic renal failure in the first… Expand
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Highly Cited
2008
Highly Cited
2008
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
Nek8 is a serine/threonine kinase that is mutated in the jck (juvenile cystic kidneys) mouse, a model of autosomal recessive… Expand
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Review
2005
Review
2005
Caught Nek-ing: cilia and centrioles
The Nek family of cell-cycle kinases is widely represented in eukaryotes and includes numerous proteins that were described only… Expand
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Highly Cited
2004
Highly Cited
2004
A NIMA-related kinase, Fa2p, localizes to a novel site in the proximal cilia of Chlamydomonas and mouse kidney cells.
Polycystic kidney disease and related syndromes involve dysregulation of cell proliferation in conjunction with ciliary defects… Expand
2004
2004
Feline polycystic kidney disease is linked to the PKD1 region
Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder (1/1000) in humans characterized by fluid… Expand
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Highly Cited
2002
Highly Cited
2002
Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2*
We describe the isolation, cloning, and characterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate… Expand
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