NEK9 protein, human

Known as: Nercc1 protein, human, Serine/Threonine-Protein Kinase Nek9, Nek8 
Serine/threonine-protein kinase Nek9 (979 aa, ~107 kDa) is encoded by the human NEK9 gene. This protein is involved in the progression of mitosis and… (More)
National Institutes of Health

Related topics

Related topics

12 relations
Casein Kinase I Isoform Delta, humanCell Cycle ProgressionChromosome SegregationEnzyme Gene
(More)

Broader (1)

NIMA-Related Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.
Ciliopathies are a group of genetic multi-systemic disorders related to dysfunction of the primary cilium, a sensory organelle… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
2013
2013
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.
Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. NEK8/NPHP9 is a ciliary… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2013
2013
Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression.
Mutations affecting the integrity and function of cilia have been identified in various genes over the last decade accounting for… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2012
2012
The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.
Nephronophthisis (NPH) is a genetically heterogenous kidney disease and represents the most common genetic cause for end-stage… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis
Mutations in the never-in-mitosis A-related kinase, Nek8, are associated with cystic kidney disease in both humans and mice, with… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 6
  • figure 7
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
BACKGROUND Nephronophthisis associated ciliopathies (NPHP-AC) comprise a group of autosomal recessive cystic kidney diseases that… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2007
2007
Defects in ciliary localization of Nek8 is associated with cystogenesis
Mutations in the human NIMA (Never in Mitosis gene A)-related kinase 8 (Nek8) are associated with a rare form of the juvenile… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2005
Review
2005
Caught Nek-ing: cilia and centrioles.
The Nek family of cell-cycle kinases is widely represented in eukaryotes and includes numerous proteins that were described only… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
2004
2004
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.
The family of human Nek (NIMA Related Kinase) kinases currently contains 11 members. We have identified Nek8 as a new member of… (More)
Is this relevant?