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NEDD8 protein, human

Known as: Ubiquitin-Like Protein Nedd8, NEDD-8, Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 
NEDD8 (81 aa, ~9 kDa) is encoded by the human NEDD8 gene. This protein plays a role in the mediation of ubiquitination.
National Institutes of Health

Related topics

Related topics

8 relations
Cell NucleusGenes, RegulatorMorphogenesisNEDD8 gene

Broader (1)

Ubiquitins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Nedd8 on cullin: building an expressway to protein destruction
This review summarizes recent advances concerning the Nedd8 regulatory pathway in four areas. One, substantial progress has been… 
Highly Cited
2003
Highly Cited
2003
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Highly Cited
2003
Highly Cited
2003
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8
Post-translational modification by ubiquitin-like proteins (Ublps) is an essential cellular regulatory mechanism. The Ublp NEDD8… 
Highly Cited
2002
Highly Cited
2002
Cytoskeletal Regulation by the Nedd8 Ubiquitin-Like Protein Modification Pathway
The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements… 
Highly Cited
2000
Highly Cited
2000
Conjugation of Nedd8 to CUL1 Enhances the Ability of the ROC1-CUL1 Complex to Promote Ubiquitin Polymerization*
The SCF-ROC1 ubiquitin-protein isopeptide ligase (E3) ubiquitin ligase complex targets the ubiquitination and subsequent… 
Highly Cited
2000
Highly Cited
2000
Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα
ABSTRACT Regulation of NF-κB occurs through phosphorylation-dependent ubiquitination of IκBα, which is degraded by the 26S… 
Highly Cited
2000
Highly Cited
2000
Covalent modifier NEDD8 is essential for SCF ubiquitin‐ligase in fission yeast
A ubiquitin‐like modifier, NEDD8, is covalently attached to cullin‐family proteins, but its physiological role is poorly… 
Highly Cited
2000
Highly Cited
2000
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.
Temporal control of p27(Kip1) (p27) degradation imposes periodicity in its activity during cell cycle progression and its… 
Highly Cited
1999
Highly Cited
1999
Covalent modification of all members of human cullin family proteins by NEDD8
Recently we found that NEDD8, a ubiquitin-like protein, was linked covalently to human cullin-4A (abbreviated Cul-4A) by a new… 
Highly Cited
1998
Highly Cited
1998
A new NEDD8-ligating system for cullin-4A.
NEDD8 is a ubiquitin (Ub)-like protein. Here we report a novel ubiquitinylation-related pathway for modification by NEDD8. NEDD8… 
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