NEDD8 Activating Enzyme

Known as: NEDD8 Activating E1 Enzyme, UBA3-NAE1 E1 Enzyme, NAE 
NEDD8 activating enzyme is comprised of NEDD8-activating enzyme E1 regulatory subunit and NEDD8-activating enzyme E1 catalytic subunit. This protein… (More)
National Institutes of Health

Papers overview

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2013
2013
MLN4924 is an investigational small-molecule inhibitor of the NEDD8-activating enzyme (NAE) in phase I clinical trials. NAE… (More)
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Highly Cited
2012
Highly Cited
2012
Radiotherapy is used in locally advanced pancreatic cancers in which it can improve survival in combination with gemcitabine… (More)
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Highly Cited
2012
Highly Cited
2012
Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is needed for proteolytic degradation of… (More)
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2012
2012
Inhibition of NEDD8-activating enzyme (NAE) has emerged as a highly promising approach to treat cancer through the adenosine… (More)
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Highly Cited
2011
Highly Cited
2011
Loss of NEDD8-activating enzyme (NAE) function by siRNA knockdown or inhibition by the small molecule NAE inhibitor MLN4924 leads… (More)
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Highly Cited
2010
Highly Cited
2010
NEDD8 activating enzyme (NAE) has been identified as an essential regulator of the NEDD8 conjugation pathway, which controls the… (More)
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Highly Cited
2010
Highly Cited
2010
The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924… (More)
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Highly Cited
2010
Highly Cited
2010
MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor. In most cancer cells tested, inhibition… (More)
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Highly Cited
2009
Highly Cited
2009
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of… (More)
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Highly Cited
2009
Highly Cited
2009
E3 ubiquitin ligases regulate many dynamic cellular processes important for cancer cell survival. Together with ubiquitin… (More)
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