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The blood–brain barrier (BBB) is essential for maintaining homeostasis within the central nervous system (CNS) and is a… Expand Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic development and adult homeostasis. Wnt… Expand Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically… Expand Mutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or the ligand Norrin disrupt retinal… Expand Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4… Expand Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the… Expand Coats' disease is characterized by abnormal retinal vascular development (so-called 'retinal telangiectasis') which results in… Expand It has been known for many years that adipocytes express high affinity ACTH and alpha-melanocyte stimulating hormone (MSH… Expand Familial exudative vitreoretinopathy (FEVR) is a hereditary disorder characterized by an abnormality of the peripheral retina… Expand A cDNA clone for cytosolic nucleoside diphosphate (NDP) kinase was isolated from a cDNA library of rat skeletal muscle using… Expand