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NB1011

Known as: NB 1011, NB101.1 
A novel small molecule, and a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine with antitumor property. NB1011 is selectively… Expand
National Institutes of Health

Papers overview

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2012
2012
Hepatitis C virus is an infectious disease affecting millions of people worldwide and causing chronic liver disease. The current… Expand
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2005
2005
The phosphoramidate technology we have developed has been recently applied to BVdU, leading to NB1011 (NewBiotics Inc… Expand
2004
2004
3144 Background: Resistance to fluoropyrimidines (FP) is associated with increased expression of TS. N is a pronucleotide analog… Expand
2003
2003
NB1011 [E-5-(2-bromovinyl)-2'-deoxyuridine-5'-(L-methylalaninyl)-phenylphosphoramidate], a phosphoramidate prodrug of E-5-(2… Expand
2003
2003
We have determined the kinetic parameters of human recombinant thymidylate synthase (hrTS) with its natural substrate, dUMP, and… Expand
2003
2003
To develop a shelf-stable formulation of a cancer treatment under study, the authors evaluated three approaches: cosolvent… Expand
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2002
2002
NB1011, a novel anticancer agent, targets tumor cells expressing high levels of thymidylate synthase (TS). NB1011 is converted… Expand
2002
2002
NB1011, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule anticancer agent. NB1011… Expand
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2001
2001
The in vivo administration of enzyme-inhibiting drugs for cancer and infectious disease often results in overexpression of the… Expand
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2001
2001
Tumor cell resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious problem often… Expand
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