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NANOS2 gene

Known as: nanos homolog 2 (Drosophila), NOS2, NANOS, DROSOPHILA, HOMOLOG OF, 2 
 
National Institutes of Health

Papers overview

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2017
2017
Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene
Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the… Expand
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2013
2013
nanos3 maintains germline stem cells and expression of the conserved germline stem cell gene nanos2 in the zebrafish ovary.
Female zebrafish have a prolific reproductive capacity, suggesting that a germline stem cell (GSC) population drives oocyte… Expand
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Highly Cited
2010
Highly Cited
2010
Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.
In the mouse, three genes that are homologous to the Drosophila Nanos (Nos) gene have been identified. Deletion of one of these… Expand
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Highly Cited
2010
Highly Cited
2010
NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.
Nanos is one of the evolutionarily conserved proteins implicated in germ cell development. We have previously shown that NANOS2… Expand
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Highly Cited
2009
Highly Cited
2009
The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3.
Spermatogonial stem cells (SSCs) reside in undifferentiated type-A spermatogonia and contribute to continuous spermatogenesis by… Expand
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Highly Cited
2009
Highly Cited
2009
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells.
Stem cells give rise to differentiated cell types but also preserve their undifferentiated state through cell self-renewal. With… Expand
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Highly Cited
2009
Highly Cited
2009
Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling
BACKGROUND During normal physical activities cartilage experiences dynamic compressive forces that are essential to maintain… Expand
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Highly Cited
2008
Highly Cited
2008
Nanos2 suppresses meiosis and promotes male germ cell differentiation.
In mouse fetal gonads, retinoic acid (RA) induces meiosis in the female germ cells, whereas the male germ cells never enter… Expand
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Highly Cited
2003
Highly Cited
2003
Conserved role of nanos proteins in germ cell development.
In Drosophila, maternally supplied Nanos functions in the migration of primordial germ cells (PGCs) into the gonad; in mice… Expand
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Highly Cited
2002
Highly Cited
2002
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children
BACKGROUND Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO… Expand
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