NAD-dependent histone deacetylase activity

Known as: SIR2 
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that… (More)
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Highly Cited
2008
Highly Cited
2008
The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2… (More)
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Highly Cited
2007
Highly Cited
2007
Sir2 (silent information regulator 2) is an NAD(+)-dependent histone deacetylase that contributes to longevity in yeast. SIRT1, a… (More)
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Highly Cited
2004
Highly Cited
2004
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases… (More)
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Review
2004
Review
2004
Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide… (More)
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Highly Cited
2004
Highly Cited
2004
Recent studies have revealed new roles for NAD and its derivatives in transcriptional regulation. The evolutionarily conserved… (More)
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Highly Cited
2004
Highly Cited
2004
Axonal degeneration is an active program of self-destruction that is observed in many physiological and pathological settings. In… (More)
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Highly Cited
2003
Highly Cited
2003
The silent information regulator 2 protein (Sir2p) of Saccharomyces cerevisiae is an NAD-dependent histone deacetylase that plays… (More)
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Highly Cited
2000
Highly Cited
2000
Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and… (More)
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Highly Cited
2000
Highly Cited
2000
The yeast Sir2 protein, required for transcriptional silencing, has an NAD(+)-dependent histone deacetylase (HDA) activity. Yeast… (More)
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