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N7-ethylguanine

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2013
012319742013

Related topics

Related topics

2 relations

Broader (1)

Guanine
analogs & derivatives

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
N7-ethylguanine
Guanine
analogs & derivatives

Papers overview

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2013
2013
Simultaneous quantitative analysis of N3-ethyladenine and N7-ethylguanine in human leukocyte deoxyribonucleic acid by stable isotope dilution capillary liquid chromatography-nanospray ionization…
Cigarette smoke contains ethylating agents which damage DNA producing ethylated DNA adducts, such as N(3)-ethyladenine (3-EtAde… (More)
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2011
2011
N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.
Genotoxic tolerance to low-level exposure of monofunctional alkylating agents is compound specific, with the mechanism pertaining… (More)
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2006
2006
Quantitative determination of urinary N7-ethylguanine in smokers and non-smokers using an isotope dilution liquid chromatography/tandem mass spectrometry with on-line analyte enrichment.
Previous studies demonstrated the presence of unknown direct-acting ethylating agents arising from cigarette smoke. We… (More)
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1998
1998
DNA adducts, mutant frequencies, and mutation spectra in various organs of lambda lacZ mice exposed to ethylating agents.
To investigate tissue-specific relations between DNA adducts and mutagenesis in vivo, lambda lacZ transgenic mice were treated i… (More)
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1996
1996
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of lambda(lacZ) transgenic mice treated with N-ethyl-N-nitrosourea.
LacZ transgenic mice are suitable for short-term mutagenicity studies in vivo. Mutagenicity in these mice is determined in the… (More)
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1991
1991
The isolation of monoclonal antibodies selected for the detection of imidazole ring-opened N7-ethylguanine in purified DNA and in cells in situ. Crossreaction with methyl, 2-hydroxyethyl and sulphur…
Monoclonal antibodies have been obtained against imidazole ring-opened N7-ethylguanine (RON7-EtGua) in DNA. The antibodies were… (More)
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1989
1989
Synthesis of N7-ethyldeoxyguanosine 5'-triphosphate and placement of N7-ethylguanine in a specific site in a synthetic oligodeoxyribonucleotide.
N7-Ethyldeoxyguanosine 5'-triphosphate (N7-Etd-GTP) was synthesized by direct ethylation of dGTP with diethyl sulfate and… (More)
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1986
1986
Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis.
Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma… (More)
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1983
1983
Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.
The carcinogen 1,2-dibromoethane and reduced glutathione (GSH) were irreversibly bound to calf thymus DNA in equimolar amounts… (More)
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Highly Cited
1974
Highly Cited
1974
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.
The nervous system specificity of the carcinogenic effect of N-ethyl-N-nitrosourea in rats at the perinatal age is of particular… (More)
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