N7-ethylguanine

Cigarette smoke contains ethylating agents which damage DNA producing ethylated DNA adducts, such as N(3)-ethyladenine (3-EtAde… Expand

Areca nut is a carcinogen to humans and has been strongly associated with oral premalignant and malignant diseases. Previous… Expand

Previous studies demonstrated the presence of unknown direct-acting ethylating agents arising from cigarette smoke. We… Expand

My son enjoys visiting my lab on weekends because the university internet connection is much faster than our home modem… Expand

To investigate tissue‐specific relations between DNA adducts and mutagenesis in vivo, λlacZ transgenic mice were treated i.p… Expand

We compared the induction of gene mutations and chromosomal aberrations by ethylating agents in lacZ transgenic mice (Muta Mouse… Expand

Monoclonal antibodies have been obtained against imidazole ring-opened N7-ethylguanine (RON7-EtGua) in DNA. The antibodies were… Expand

Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma… Expand

[3H-Et]Nitrosourea was administered to male (101 X C3H) mice by i.p. injection at exposure levels of 10 mg/kg or 100 mg/kg. At… Expand

The nervous system specificity of the carcinogenic effect of N-ethyl-N-nitrosourea in rats at the perinatal age is of particular… Expand