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N7-ethylguanine

National Institutes of Health

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Guanine
analogs & derivatives

Papers overview

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2011
2011
N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.
Genotoxic tolerance to low-level exposure of monofunctional alkylating agents is compound specific, with the mechanism pertaining… 
2006
2006
Quantitative determination of urinary N7-ethylguanine in smokers and non-smokers using an isotope dilution liquid chromatography/tandem mass spectrometry with on-line analyte enrichment.
Previous studies demonstrated the presence of unknown direct-acting ethylating agents arising from cigarette smoke. We… 
1996
1996
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of λlacZ transgenic mice treated with N-ethyl-N-nitrosourea
LacZ transgenic mice are suitable for short-term mutagenicity studies in vivo. Mutagenicity in these mice is determined in the… 
1996
1996
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of lambda(lacZ) transgenic mice treated with N-ethyl-N-nitrosourea.
LacZ transgenic mice are suitable for short-term mutagenicity studies in vivo. Mutagenicity in these mice is determined in the… 
1989
1989
Synthesis of N7-ethyldeoxyguanosine 5'-triphosphate and placement of N7-ethylguanine in a specific site in a synthetic oligodeoxyribonucleotide.
1987
1987
[Effect of molybdenum Mo on the alkylation of DNA in the liver of rats treated with 14C-diethylnitrosamine].
Effect of molybdenum on the alkylation of DNA in the liver of rats treated with 14C-diethylnitrosamine was studied. When… 
1986
1986
Chemical dosimetry of ethyl nitrosourea in the mouse testis.
1986
1986
Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis.
Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma… 
1986
1986
DNA damage, repair, replication, and tumor incidence in the BDIV rat strain following administration of N-ethyl-N-nitrosourea.
Berlin-Druckrey (BD-IV) rats were used to evaluate the level of neoplastic transformation, initiation of DNA damage and repair… 
1976
1976
Molecular and Cellular Mechanisms in Nervous System-specific Carcinogenesis by N-Ethyl-N-nitrosourea
A single pulse of N-ethyl-N-nitrosourea (ENU), applied to BDIX rats during the perinatal age, specifically results in a high… 
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