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N-phthalimidomethyl-ketomethylene

Known as: N-alpha-phthalimidomethyl-ketomethylene tripeptide 
National Institutes of Health

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1 relation

Broader (1)

Phthalimides

Papers overview

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2017
2017
First Application of the Dakin-West Reaction to Fmoc Chemistry : Synthesis of the ketomethylene tripeptide Fmoc-N α-Asp ( t Bu )-( R , S ) Tyr ( t Bu ) Ψ ( COCH 2 )
A practical synthesis of a tripeptide containing a ketomethylene isostere, suitably protected for introduction in Fmoc SPPS, has… 
2010
2010
Preparation of phthalimidomethyl polysulfone affinity membrane and its removal properties of p-nitrophenol
Chloromethylated polysulfone was transformed into phthalimidomethylated polysulfone via the Gabriel reaction using sodium salt of… 
2004
2004
Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: design, synthesis, stability, and biological investigations.
Five dipeptidomimetic-based model prodrugs containing ketomethylene amide bond replacements were synthesized from readily… 
1998
1998
Exploration of the importance of the P2-P3-NHCO-moiety in a potent di- or tripeptide inhibitor of calpain I: insights into the development of nonpeptidic inhibitors of calpain I.
1995
1995
Thrombin inhibitors based on ketone derivatives of arginine and lysine.
Much attention is currently focused on inhibitors of thrombin as potential anticoagulants. We have previously reported thrombin… 
1994
1994
HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs.
1992
1992
Synthesis and Inhibitory Activities against Aminopeptidase B and Enkephalin‐Degrading Enzymes of Ketomethylene Dipeptide Analogues of Arphamenines
Three ketomethylene pseudodideptide analogues [(S)Lysψ(COCH2)(R and S)Phe (14 or 15 and 15 or 14) and (S)Lysψ(COCH2)(ζTrp (19… 
1992
1992
Ketomethylene Analogues of Phosphoryl Dipeptides Related to Phosphoramidon: Synthesis and Inhibition of Proteases
Non‐rhamnose‐containing phosphoramidon analogues, in which the amide bond was replaced by the isosteric ketomethylene group, have… 
1963
1963
Total Synthesis of Unsaturated Phosphatidylserine and its Activity in Clotting Systems
NATURAL phosphatidylserine (PS) has been found to be a potent anticoagulant1,2. We describe here the comparable activity of… 
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