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N-benzyloxycarbonyl-valyl-phenylalanine methyl ester

Known as: N-benzyloxycarbonyl-Val-Phe methyl ester, Z-Val-Phe-OMe, Z-Val-Phe methyl ester 
 
National Institutes of Health

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Broader (1)

Dipeptides

Papers overview

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Highly Cited
2005
Highly Cited
2005
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate.
A practical asymmetric synthesis of both enantiomers of the immunosuppressive FTY720-phosphate (2) was accomplished, and the… Expand
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Highly Cited
2001
Highly Cited
2001
Characterization of Fortilin, a Novel Antiapoptotic Protein*
Apoptosis is meticulously controlled in living organisms. Its dysregulation has been shown to play a key role in a number of… Expand
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Highly Cited
2001
Highly Cited
2001
Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells.
PURPOSE Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal, a side-product of glycolysis… Expand
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Highly Cited
2000
Highly Cited
2000
Involvement of Caspase‐3‐Like Protease in the Mechanism of Cell Death Following Focally Evoked Limbic Seizures
The cysteine protease caspase‐3 may be involved in the mechanism of cell death following seizures. Using a rat model of focally… Expand
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Highly Cited
2000
Highly Cited
2000
Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis.
Cytotoxic endoribonucleases (RNases) possess a potential for use in cancer therapy. However, the molecular determinants of RNase… Expand
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Highly Cited
1999
Highly Cited
1999
Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia
An essential role for caspases in programmed neuronal cell death has been demonstrated in various in vitro studies, and synthetic… Expand
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Highly Cited
1998
Highly Cited
1998
Bax directly induces release of cytochrome c from isolated mitochondria.
Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial… Expand
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Highly Cited
1998
Highly Cited
1998
Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways
Murine L929 fibrosarcoma cells were transfected with the human Fas (APO-1/CD95) receptor, and the role of various caspases in Fas… Expand
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Highly Cited
1988
Highly Cited
1988
Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase.
A series of N-blocked L-proline-containing compounds and their derivatives were synthesized. Their inhibitory activities for… Expand
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Highly Cited
1983
Highly Cited
1983
An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in…
The degradation of thyroliberin (less than Glu-His-Pro-NH2) to its component amino acids by the soluble fraction of guinea pig… Expand
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