N-Formylmethionine Leucyl-Phenylalanine

Known as: L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-, fMLP (formyl-met-leu-phe), N Formylmethionine Leucyl Phenylalanine 
A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them… (More)
National Institutes of Health

Related topics

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22 relations

Broader (2)

Chemotactic FactorsPeptides

Narrower (12)

F-Met-Leu-PheFormylmethionyl PeptideN-formyl-methionyl-leucyl-phenylalanyl-phenylalanineN-formylmethionine-thioamide-leucyl-phenylalanine methyl ester
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FPR1 geneIn Bloodagonistsanalogs & derivatives
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Papers overview

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Review
2007
Review
2007
On the origin of biochemistry at an alkaline hydrothermal vent.
A model for the origin of biochemistry at an alkaline hydrothermal vent has been developed that focuses on the acetyl-CoA (Wood… (More)
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Highly Cited
2000
Highly Cited
2000
Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy.
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Free oxygen radicals have been… (More)
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Highly Cited
1999
Highly Cited
1999
A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells
We have previously reported (Badolato, R., J.M. Wang, W.J. Murphy, A. R. Lloyd, D.F. Michiel, L.L. Bausserman, D.J. Kelvin, and J… (More)
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Highly Cited
1998
Highly Cited
1998
The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.
The oxazolidinones represent a new class of antimicrobial agents which are active against multidrug-resistant staphylococci… (More)
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Highly Cited
1998
Highly Cited
1998
p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils.
Human neutrophils undergo apoptosis spontaneously when cultured in vitro; however, the signal transduction pathways involved… (More)
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Highly Cited
1997
Highly Cited
1997
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.
The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl… (More)
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Highly Cited
1996
Highly Cited
1996
Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils.
Reports that interleukin-8 (IL-8) induces the infiltration of neutrophils followed by T-cells into injection sites led us to… (More)
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Highly Cited
1993
Highly Cited
1993
Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils
In human intestinal disease induced by Salmonella typhimurium, transepithelial migration of neutrophils (PMN) rapidly follows… (More)
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Highly Cited
1992
Highly Cited
1992
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion…
Corticosteroids are the preeminent antiinflammatory agents although the molecular mechanisms that impart their efficacy have not… (More)
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Highly Cited
1984
Highly Cited
1984
Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.
Chemotactic factor-enriched butanol extracts from Escherichia coli culture filtrates were fractionated and purified by high… (More)
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