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N-Formylmethionine Leucyl-Phenylalanine

Known as: L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-, fMLP (formyl-met-leu-phe), N Formylmethionine Leucyl Phenylalanine 
A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them… Expand
National Institutes of Health

Related topics

Related topics

22 relations

Broader (2)

Chemotactic FactorsPeptides

Narrower (12)

F-Met-Leu-PheFormylmethionyl PeptideN-formyl-methionyl-leucyl-phenylalanyl-phenylalanineN-formylmethionine-thioamide-leucyl-phenylalanine methyl ester
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FPR1 geneIn Bloodagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family
Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G protein-coupled receptors that are expressed… Expand
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Review
2006
Review
2006
On the origin of biochemistry at an alkaline hydrothermal vent
  • W. Martin, M. Russell
  • Philosophical Transactions of the Royal Society B…
  • 2006
    • Corpus ID: 19719196
A model for the origin of biochemistry at an alkaline hydrothermal vent has been developed that focuses on the acetyl-CoA (Wood… Expand
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Highly Cited
2000
Highly Cited
2000
Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy.
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Free oxygen radicals have been… Expand
Highly Cited
1998
Highly Cited
1998
The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria
ABSTRACT The oxazolidinones represent a new class of antimicrobial agents which are active against multidrug-resistant… Expand
Highly Cited
1997
Highly Cited
1997
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.
The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils (*)
Reports that interleukin-8 (IL-8) induces the infiltration of neutrophils followed by T-cells into injection sites led us to… Expand
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Highly Cited
1993
Highly Cited
1993
Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
Neutrophil apoptosis leads to macrophage ingestion of intact senescent neutrophils. This may represent a neutrophil removal… Expand
Highly Cited
1993
Highly Cited
1993
Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils
In human intestinal disease induced by Salmonella typhimurium, transepithelial migration of neutrophils (PMN) rapidly follows… Expand
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Highly Cited
1984
Highly Cited
1984
Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.
Chemotactic factor-enriched butanol extracts from Escherichia coli culture filtrates were fractionated and purified by high… Expand
Highly Cited
1977
Highly Cited
1977
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.
Synthetic N-formylmethionyl peptides are chemotactic attractants for human polymorphonuclear leukocytes. The well-defined… Expand
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