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N-Formylmethionine Leucyl-Phenylalanine
Known as:
L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-
, fMLP (formyl-met-leu-phe)
, N Formylmethionine Leucyl Phenylalanine
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A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them…
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National Institutes of Health
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Related topics
Related topics
22 relations
Broader (2)
Chemotactic Factors
Peptides
Narrower (12)
F-Met-Leu-Phe
Formylmethionyl Peptide
N-formyl-methionyl-leucyl-phenylalanyl-phenylalanine
N-formylmethionine-thioamide-leucyl-phenylalanine methyl ester
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FPR1 gene
In Blood
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
A conserved threonine within Escherichia coli leucyl-tRNA synthetase prevents hydrolytic editing of leucyl-tRNALeu.
R. S. Mursinna
,
T. Lincecum
,
S. Martinis
Biochemistry
2001
Corpus ID: 23224012
Aminoacyl-tRNA synthetases ensure the fidelity of protein synthesis by accurately selecting and activating cognate amino acids…
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Highly Cited
1991
Highly Cited
1991
Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases.
Virgilio Evangelista
,
G. Rajtar
,
G. D. Gaetano
,
JG White
,
C. Cerletti
Blood
1991
Corpus ID: 9352639
Human polymorphonuclear leukocytes (PMN) activated by fMLP (in the presence of CaCl2, fibrinogen, and cytochalasin B) were able…
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Highly Cited
1988
Highly Cited
1988
Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization.
B. Cronstein
,
Sara B. Kramer
,
Elliot D. Rosenstein
,
H. Korchak
,
Gerald Weissmann
,
Rochelle Hirschhorn
Biochemical Journal
1988
Corpus ID: 37977466
We have recently demonstrated that adenosine, acting via adenosine A2 receptors, inhibits generation of superoxide anions (O2…
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Highly Cited
1986
Highly Cited
1986
Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.
T. Takenawa
,
J. Ishitoya
,
Y. Nagai
Journal of Biological Chemistry
1986
Corpus ID: 11680764
The effect of prostaglandin E2 (PGE2), forskolin, and dibutyryl cAMP on arachidonic acid release, inositol phospholipid…
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Review
1986
Review
1986
Regulation of expression of human granulocyte/macrophage colony-stimulating factor.
Jefferson Y. Chan
,
D. Slamon
,
Stephen D. Nimer
,
David W. Golde
,
Judy C. Gasson
Proceedings of the National Academy of Sciences…
1986
Corpus ID: 10315588
Colony-stimulating factors (CSFs) are glycoproteins that stimulate the growth of hematopoietic progenitors and enhance the…
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Highly Cited
1986
Highly Cited
1986
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.
S. Pontremoli
,
E. Melloni
,
+4 authors
B. Horecker
Journal of Biological Chemistry
1986
Corpus ID: 8435699
Low concentrations of phorbol 12-myristate 13-acetate (PMA) elicit a specific response in human neutrophils, characterized by the…
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Highly Cited
1984
Highly Cited
1984
Chemotactic peptide-induced changes in neutrophil actin conformation
P. Wallace
,
R. Wersto
,
C. Packman
,
M. Lichtman
Journal of Cell Biology
1984
Corpus ID: 7213164
The effect of the chemotatic peptide, N- formylmethionylleucylphenylalanine (FMLP), on actin conformation in human neutrophils…
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Highly Cited
1984
Highly Cited
1984
Secretagogue-induced phosphoinositide metabolism in human leucocytes.
R. Dougherty
,
P. P. Godfrey
,
P. C. Hoyle
,
J. Putney
,
R. Freer
Biochemical Journal
1984
Corpus ID: 20475993
The relationship between receptor binding of the formylated peptide chemoattractant formylmethionylleucylphenylalanine (fMet-Leu…
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Highly Cited
1982
Highly Cited
1982
A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine.
W. Jubiz
,
O. Rådmark
,
+5 authors
B. Samuelsson
Journal of Biological Chemistry
1982
Corpus ID: 6777946
Stimulation of human polymorphonuclear leukocytes with the chemotactic peptide formylmethionylleucylphenylalanine led to the…
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Highly Cited
1980
Highly Cited
1980
Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. Comparison with ionophore A23187.
G. Bokoch
,
P. Reed
Journal of Biological Chemistry
1980
Corpus ID: 36821279
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