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N-Formylmethionine Leucyl-Phenylalanine

Known as: L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-, fMLP (formyl-met-leu-phe), N Formylmethionine Leucyl Phenylalanine 
A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (2)

Chemotactic FactorsPeptides

Narrower (12)

F-Met-Leu-PheFormylmethionyl PeptideN-formyl-methionyl-leucyl-phenylalanyl-phenylalanineN-formylmethionine-thioamide-leucyl-phenylalanine methyl ester
FPR1 geneIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
A conserved threonine within Escherichia coli leucyl-tRNA synthetase prevents hydrolytic editing of leucyl-tRNALeu.
Aminoacyl-tRNA synthetases ensure the fidelity of protein synthesis by accurately selecting and activating cognate amino acids… 
Highly Cited
1991
Highly Cited
1991
Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases.
Human polymorphonuclear leukocytes (PMN) activated by fMLP (in the presence of CaCl2, fibrinogen, and cytochalasin B) were able… 
Highly Cited
1988
Highly Cited
1988
Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization.
We have recently demonstrated that adenosine, acting via adenosine A2 receptors, inhibits generation of superoxide anions (O2… 
Highly Cited
1986
Highly Cited
1986
Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.
The effect of prostaglandin E2 (PGE2), forskolin, and dibutyryl cAMP on arachidonic acid release, inositol phospholipid… 
Review
1986
Review
1986
Regulation of expression of human granulocyte/macrophage colony-stimulating factor.
Colony-stimulating factors (CSFs) are glycoproteins that stimulate the growth of hematopoietic progenitors and enhance the… 
Highly Cited
1986
Highly Cited
1986
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.
Low concentrations of phorbol 12-myristate 13-acetate (PMA) elicit a specific response in human neutrophils, characterized by the… 
Highly Cited
1984
Highly Cited
1984
Chemotactic peptide-induced changes in neutrophil actin conformation
The effect of the chemotatic peptide, N- formylmethionylleucylphenylalanine (FMLP), on actin conformation in human neutrophils… 
Highly Cited
1984
Highly Cited
1984
Secretagogue-induced phosphoinositide metabolism in human leucocytes.
The relationship between receptor binding of the formylated peptide chemoattractant formylmethionylleucylphenylalanine (fMet-Leu… 
Highly Cited
1982
Highly Cited
1982
A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine.
Stimulation of human polymorphonuclear leukocytes with the chemotactic peptide formylmethionylleucylphenylalanine led to the… 
Highly Cited
1980
Highly Cited
1980
Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. Comparison with ionophore A23187.
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