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N2-methylguanosine is one of the most universal modified nucleosides required for proper function in transfer RNA (tRNA… Expand RATIONALE
In recent years, methylated nucleosides have been considered to be potential biomarkers to human diseases. The early… Expand Methyltransferases (MTases) form a major class of tRNA-modifying enzymes needed for the proper functioning of tRNA. Recently, RNA… Expand N(2)-methylguanosine (m(2)G) is found at position 6 in the acceptor stem of Thermus thermophilus tRNA(Phe). In this article, we… Expand The modified nucleosides N2-methylguanosine and N22-dimethylguanosine in transfer RNA occur at five positions in the D and… Expand Nucleosides are indicators of the whole-body turnover of transfer RNA. Based on the activity of cancer cells these molecules… Expand Modified nucleosides are formed at the post-transcriptional stage by chemical modification of normal nucleosides within the… Expand Methylation of the exocyclic amino group of guanine is a relatively common modification in rRNA and tRNA. Single methylation (N(2… Expand We have systematically investigated the duplex to hairpin conversion of oligoribonucleotides under the aspect of nucleobase… Expand An enzyme was purified from rat liver and leukemic rat spleen which methylates guanosine residues in tRNA to N(2)-methylguanosine… Expand