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Myeloid Leukemia, Chronic

Known as: Chronic Myeloid Leukemias, CML - Chronic Myelogenous Leukemia, CML 
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The cause of chronic myeloid leukemia (CML) is a constitutively active BCR-ABL tyrosine kinase. Imatinib inhibits this… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND In a randomized trial, 1106 patients with chronic myeloid leukemia (CML) in chronic phase were assigned to imatinib or… Expand
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Highly Cited
2002
Highly Cited
2002
Through sequencing analysis of blood or bone marrow samples from patients with chronic myeloid leukemia, we identified BCR-ABL… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is… Expand
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Review
2000
Review
2000
Chronic myeloid leukemia (CML) is probably the most extensively studied human malignancy. The discovery of the Philadelphia (Ph… Expand
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Review
1999
Review
1999
  • C. Sawyers
  • The New England journal of medicine
  • 1999
  • Corpus ID: 22146304
Over the past twenty years, clinical and laboratory studies have led to important new insights into the biology of chronic… Expand
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Review
1999
Review
1999
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed, primitive hematopoietic progenitor cells… Expand
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