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Myeloid Leukemia, Chronic
Known as:
Chronic Myeloid Leukemias
, CML - Chronic Myelogenous Leukemia
, CML
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A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can…
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National Institutes of Health
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Related topics
Related topics
45 relations
10 ML Idarubicin Hydrochloride 1 MG/ML Injection
ABL1 gene
ABL1 wt Allele
Acute Basophilic Leukemia
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Broader (2)
Chronic leukemia
Neoplasms
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013.
M. Baccarani
,
M. Deininger
,
+29 authors
R. Hehlmann
Blood
2013
Corpus ID: 718953
Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of…
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Highly Cited
2013
Highly Cited
2013
Cancer statistics, 2013
R. Siegel
,
D. Naishadham
,
A. Jemal
Ca
2013
Corpus ID: 24926725
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the…
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Highly Cited
2012
Highly Cited
2012
Avogadro: an advanced semantic chemical editor, visualization, and analysis platform
M. Hanwell
,
D. Curtis
,
David C. Lonie
,
T. Vandermeersch
,
E. Zurek
,
G. Hutchison
Journal of Cheminformatics
2012
Corpus ID: 13597501
BackgroundThe Avogadro project has developed an advanced molecule editor and visualizer designed for cross-platform use in…
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Highly Cited
2010
Highly Cited
2010
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia.
G. Saglio
,
Dong-Wook Kim
,
+13 authors
H. Kantarjian
New England Journal of Medicine
2010
Corpus ID: 21150370
BACKGROUND Nilotinib has been shown to be a more potent inhibitor of BCR-ABL than imatinib. We evaluated the efficacy and safety…
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Highly Cited
2006
Highly Cited
2006
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia.
B. Druker
,
F. Guilhot
,
+29 authors
R. Larson
New England Journal of Medicine
2006
Corpus ID: 21772851
BACKGROUND The cause of chronic myeloid leukemia (CML) is a constitutively active BCR-ABL tyrosine kinase. Imatinib inhibits this…
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Highly Cited
2003
Highly Cited
2003
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.
S. O’Brien
,
F. Guilhot
,
+22 authors
B. Druker
New England Journal of Medicine
2003
Corpus ID: 20464466
BACKGROUND Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic…
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Highly Cited
2001
Highly Cited
2001
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
B. Druker
,
M. Talpaz
,
+8 authors
C. Sawyers
New England Journal of Medicine
2001
Corpus ID: 8399298
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine…
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Highly Cited
2001
Highly Cited
2001
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.
B. Druker
,
C. Sawyers
,
+5 authors
M. Talpaz
New England Journal of Medicine
2001
Corpus ID: 26116914
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is…
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Review
2000
Review
2000
The molecular biology of chronic myeloid leukemia.
M. Deininger
,
J. Goldman
,
J. Melo
Blood
2000
Corpus ID: 1044492
Chronic myeloid leukemia (CML) is probably the most extensively studied human malignancy. The discovery of the Philadelphia (Ph…
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Review
1999
Review
1999
The biology of chronic myeloid leukemia.
S. Faderl
,
M. Talpaz
,
Z. Estrov
,
S. O’Brien
,
R. Kurzrock
,
H. Kantarjian
New England Journal of Medicine
1999
Corpus ID: 6537526
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed, primitive hematopoietic progenitor cells…
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