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Myelodysplastic Syndrome with Isolated del(5q)

Known as: Myelodysplastic Syndrome Associated with Isolated del (5q) Chromosome Abnormality, 5q minus syndrome NOS, Myelodysplastic syndrome with 5q deletion 
A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is… 
National Institutes of Health

Related topics

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13 relations
Anemia, MacrocyticBone MarrowBone marrow stem cellChromosome 5, trisomy 5q
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Papers overview

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Highly Cited
2011
Highly Cited
2011
Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome.
Large chromosomal deletions are among the most common molecular abnormalities in cancer, yet the identification of relevant genes… 
Highly Cited
2011
Highly Cited
2011
Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome
BackgroundMyelodysplastic syndrome with isolated chromosome 5q deletion (5q- syndrome) is a clonal stem cell disorder… 
Review
2010
Review
2010
Ribosomopathies: human disorders of ribosome dysfunction.
Ribosomopathies compose a collection of disorders in which genetic abnormalities cause impaired ribosome biogenesis and function… 
Review
2010
Review
2010
Advances in the 5q- syndrome.
The 5q- syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The… 
Highly Cited
2008
Highly Cited
2008
Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes
We have previously demonstrated haploinsufficiency of the ribosomal gene RPS14, which is required for the maturation of 40S… 
Highly Cited
2007
Highly Cited
2007
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q− syndrome patients
Myelodysplastic syndromes (MDSs) are a group of hematopoietic stem cell disorders characterized by ineffective hematopoiesis and… 
Highly Cited
2002
Highly Cited
2002
Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome.
The 5q- syndrome is the most distinct of the myelodysplastic syndromes, and the molecular basis for this disorder remains unknown… 
Highly Cited
1998
Highly Cited
1998
Molecular cytogenetic delineation of the critical deleted region in the 5q− syndrome
The 5q− syndrome is a distinct type of myelodysplastic syndrome (MDS) characterised by refractory anaemia, morphological… 
Highly Cited
1993
Highly Cited
1993
The 5q- syndrome: a single-institution study of 43 consecutive patients.
A favorable prognosis and a low rate of leukemic transformation has been attributed to the 5q- syndrome, a myelodysplastic… 
Highly Cited
1991
Highly Cited
1991
Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion.
A high proportion of patients with myelodysplasia show characteristic karyotypic abnormalities in bone marrow cells. The most… 
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