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Myelodysplastic Syndrome with Isolated del(5q)

Known as: Myelodysplastic Syndrome Associated with Isolated del (5q) Chromosome Abnormality, 5q minus syndrome NOS, Myelodysplastic syndrome with 5q deletion 
A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Anemia, MacrocyticBone MarrowBone marrow stem cellChromosome 5, trisomy 5q
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome.
Large chromosomal deletions are among the most common molecular abnormalities in cancer, yet the identification of relevant genes… Expand
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2011
2011
Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome
BackgroundMyelodysplastic syndrome with isolated chromosome 5q deletion (5q- syndrome) is a clonal stem cell disorder… Expand
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Review
2010
Review
2010
Advances in the 5q- syndrome.
The 5q- syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The… Expand
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Review
2010
Review
2010
Ribosomopathies: human disorders of ribosome dysfunction.
Ribosomopathies compose a collection of disorders in which genetic abnormalities cause impaired ribosome biogenesis and function… Expand
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Highly Cited
2008
Highly Cited
2008
Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes
We have previously demonstrated haploinsufficiency of the ribosomal gene RPS14, which is required for the maturation of 40S… Expand
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2008
2008
Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays.
BACKGROUND We undertook a genome wide single nucleotide polymorphism analysis of a spectrum of patients with myelodysplastic… Expand
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2008
2008
Myelodysplastic syndrome with isolated 5q deletion (5q- syndrome). A clonal stem cell disorder characterized by defective ribosome biogenesis.
In 1974 Herman van den Berghe et al. [1][1] reported a distinct hematologic disorder associated with acquired deletion of the… Expand
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Highly Cited
2007
Highly Cited
2007
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.
Myelodysplastic syndromes (MDSs) are a group of hematopoietic stem cell disorders characterized by ineffective hematopoiesis and… Expand
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Highly Cited
2002
Highly Cited
2002
Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome.
The 5q- syndrome is the most distinct of the myelodysplastic syndromes, and the molecular basis for this disorder remains unknown… Expand
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1998
1998
Molecular cytogenetic delineation of the critical deleted region in the 5q- syndrome.
The 5q- syndrome is a distinct type of myelodysplastic syndrome (MDS) characterised by refractory anaemia, morphological… Expand
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