FAQ

Myelin Basic Proteins

Known as: MBP, Myelin Basic Protein [Chemical/Ingredient], basic myelin protein 
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides… (More)

Topic mentions per year

Topic mentions per year

1971-2017
010020030019712017

Related topics

Related topics

21 relations

Narrower (9)

CGP 77116MBP protein, humanMBP-8298NBI 5788
(More)
Experimental Autoimmune EncephalomyelitisIn BloodProcess of secretionadministration & dosage
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Myelin Basic Proteins
physiological aspects
agonists
Experimental Autoimmune Encephalomyelitis
chemical synthesis
bleomycin/cisplatin/methotrexate protocol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion.
Partial injury to the spinal cord can propagate itself, sometimes leading to paralysis attributable to degeneration of initially… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study.
In experimental animal models of multiple sclerosis demyelinating antibody responses are directed against the myelin… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Transport and Localization Elements in Myelin Basic Protein mRNA
Myelin basic protein (MBP) mRNA is localized to myelin produced by oligodendrocytes of the central nervous system. MBP mRNA… (More)
  • figure 1
  • figure 2
  • table I
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Structural similarity between viral T cell epitopes and self-peptides could lead to the induction of an autoaggressive T cell… (More)
  • figure 1
  • table 1
  • table 1
  • table 2
  • figure 2
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin…
Ramified microglia in the adult central nervous system (CNS) are the principal glial element up-regulating MHC class I and II… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice.
We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and crossed them to RAG-1-deficient mice to… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
Equal numbers of CD4+ T cells recognizing myelin basic protein (MBP) and proteolipid protein (PLP) are found in the circulation… (More)
  • table 1
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.
We constructed a transgenic mouse model that mimics the human autoimmune disease multiple sclerosis in its spontaneous induction… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes
We have studied transport and localization of MBP mRNA in oligodendrocytes in culture by microinjecting labeled mRNA into living… (More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity.
Amino acid sequence homology was found between viral and host encephalitogenic protein. Immune responses were then generated in… (More)
Is this relevant?