Muscarinic Agents

Scopolamine is a high affinity muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. 5-HT3… (More)

We have recently shown that the M1 muscarinic receptor positive allosteric modulator, PQCA, improves cognitive performance in… (More)

OBJECTIVE A common rodent model in epilepsy research employs the muscarinic acetylcholine receptor (mAChR) agonist pilocarpine… (More)

UNLABELLED Neuromodulation of olfactory circuits by acetylcholine (ACh) plays an important role in odor discrimination and… (More)

The urothelium is a newly recognized sensory structure that detects bladder fullness. Pivotal to this sensory role is the release… (More)

Cholinergic stimulation of the cerebral cortex is essential for tasks requiring attention; however, there is still some debate… (More)

The cholinergic system is critically involved in the modulation of cognitive functions, including learning and memory… (More)

The optimization for selectivity and central receptor occupancy for a series of spirocyclic azetidine-piperidine inverse agonists… (More)

M5 muscarinic acetylcholine receptors expressed on ventral tegmental dopamine (DA) neurons are needed for opioid activation of DA… (More)

Acetylcholine (ACh) is a neurotransmitter acting via muscarinic and nicotinic receptors that is implicated in several cognitive… (More)