Muscarinic Acetylcholine Receptor
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Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known… Expand The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors… Expand Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family… Expand Actions of acetylcholine in the periphery are the result of activation of either the ionotropic nicotinic receptor or the… Expand Muscarinic receptors regulate a number of important basic physiologic functions including heart rate and motor and sensory… Expand Altered processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains… Expand mRNAs encoding five genetically distinct muscarinic ACh receptors are present in the CNS. Because of their pharmacological… Expand In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine… Expand Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and… Expand Despite its very potent vasodilating action in vivo, acetylcholine (ACh) does not always produce relaxation of isolated… Expand