Mre11 complex

Known as: Rad50 complex, RAD50-MRE11-NBN complex, MRX complex 
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single… (More)
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Highly Cited
2005
Highly Cited
2005
Virus infections have dramatic effects on structural and morphological characteristics of the host cell. The gene product of open… (More)
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Highly Cited
2003
Highly Cited
2003
The maintenance of genome integrity requires a rapid and specific response to many types of DNA damage. The conserved and related… (More)
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Highly Cited
2003
Highly Cited
2003
The Mre11 complex undergoes dramatic relocalization in the nuclei of gamma-irradiated and replicating human cells. In this study… (More)
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Review
2002
Review
2002
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode… (More)
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Highly Cited
2002
Highly Cited
2002
The Mre11 complex (Mre11–Rad50–Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere… (More)
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Highly Cited
2001
Highly Cited
2001
The Mre11 complex has been implicated in diverse aspects of the cellular response to DNA damage. We used in situ fractionation of… (More)
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Highly Cited
2001
Highly Cited
2001
We define a DNA damage checkpoint pathway in S. cerevisiae governed by the ATM homolog Tel1 and the Mre11 complex. In mitotic… (More)
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Highly Cited
2001
Highly Cited
2001
Mre11 complex promotes repair of DNA double-strand breaks (DSBs). Xenopus Mre11 (X-Mre11) has been cloned, and its role in DNA… (More)
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Highly Cited
2001
Highly Cited
2001
We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1… (More)
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