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Mre11 complex

Known as: Rad50 complex, RAD50-MRE11-NBN complex, MRX complex 
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response… Expand
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Highly Cited
2008
Highly Cited
2008
DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single… Expand
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Review
2004
Review
2004
The MRE11/RAD50/NBS1 complex (Mre11 complex) is a central player in most aspects of the cellular response to DNA double-strand… Expand
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Highly Cited
2003
Highly Cited
2003
The maintenance of genome integrity requires a rapid and specific response to many types of DNA damage. The conserved and related… Expand
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Review
2002
Review
2002
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode… Expand
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Highly Cited
2002
Highly Cited
2002
The Mre11 complex (Mre11–Rad50–Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT The Mre11 complex has been implicated in diverse aspects of the cellular response to DNA damage. We used in situ… Expand
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Highly Cited
2001
Highly Cited
2001
We define a DNA damage checkpoint pathway in S. cerevisiae governed by the ATM homolog Tel1 and the Mre11 complex. In mitotic… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1… Expand
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Highly Cited
2001
Highly Cited
2001
Mre11 complex promotes repair of DNA double-strand breaks (DSBs). Xenopus Mre11 (X-Mre11) has been cloned, and its role in DNA… Expand
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