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Mre11 complex

Known as: Rad50 complex, RAD50-MRE11-NBN complex, MRX complex 
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single… Expand
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Highly Cited
2005
Highly Cited
2005
The Mre11 complex (in Saccharomyces cerevisiae: Mre11, Rad50 and Xrs2) influences multiple facets of chromosome break metabolism… Expand
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Review
2004
Review
2004
The conserved Mre11 complex (Mre11, Rad50, and Nbs1) plays a role in each aspect of chromosome break metabolism. The complex acts… Expand
Highly Cited
2003
Highly Cited
2003
The maintenance of genome integrity requires a rapid and specific response to many types of DNA damage. The conserved and related… Expand
Review
2002
Review
2002
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode… Expand
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Highly Cited
2002
Highly Cited
2002
The Mre11 complex (Mre11–Rad50–Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT The Mre11 complex has been implicated in diverse aspects of the cellular response to DNA damage. We used in situ… Expand
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Highly Cited
2001
Highly Cited
2001
We define a DNA damage checkpoint pathway in S. cerevisiae governed by the ATM homolog Tel1 and the Mre11 complex. In mitotic… Expand
Highly Cited
2001
Highly Cited
2001
Mre11 complex promotes repair of DNA double-strand breaks (DSBs). Xenopus Mre11 (X-Mre11) has been cloned, and its role in DNA… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1… Expand