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Mitogen-Activated Protein Kinases

Known as: Mitogen-Activated Protein Kinase, MAP kinase, Extracellular Signal-Regulated Kinases 
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and… 
National Institutes of Health

Related topics

Related topics

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Narrower (21)

AtMPK4 protein, ArabidopsisHOG1 protein, S cerevisiaeJNK-1 protein, C elegansMK1 protein, Capsicum annuum
Calcium-Calmodulin-Dependent Protein KinasesCalcium/calmodulin-dependent protein kinaseCell Cycle ControlCell Cycle Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
SUMMARY The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to… 
Review
2004
Review
2004
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions
SUMMARY Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying… 
Review
2001
Review
2001
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.
The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite… 
Highly Cited
1998
Highly Cited
1998
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1… 
Highly Cited
1995
Highly Cited
1995
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… 
Highly Cited
1995
Highly Cited
1995
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen… 
Highly Cited
1995
Highly Cited
1995
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK… 
Review
1995
Review
1995
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*)
  • M. Karin
  • The Journal of Biological Chemistry
  • 1995
  • Corpus ID: 9181673
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The… 
Highly Cited
1995
Highly Cited
1995
Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER… 
Highly Cited
1994
Highly Cited
1994
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl… 
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