Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 206,145,714 papers from all fields of science
Search
Sign In
Create Free Account
Mitogen-Activated Protein Kinases
Known as:
Mitogen-Activated Protein Kinase
, MAP kinase
, Extracellular Signal-Regulated Kinases
Expand
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
45 relations
Narrower (21)
AtMPK4 protein, Arabidopsis
HOG1 protein, S cerevisiae
JNK-1 protein, C elegans
MK1 protein, Capsicum annuum
Expand
Calcium-Calmodulin-Dependent Protein Kinases
Calcium/calmodulin-dependent protein kinase
Cell Cycle Control
Cell Cycle Proteins
Expand
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
Marie Cargnello
,
Philippe P Roux
Microbiology and Molecular Reviews
2011
Corpus ID: 23847824
SUMMARY The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to…
Expand
Review
2004
Review
2004
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions
Philippe P Roux
,
J. Blenis
Microbiology and Molecular Biology Reviews
2004
Corpus ID: 9872565
SUMMARY Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying…
Expand
Review
2001
Review
2001
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.
J. Kyriakis
,
J. Avruch
Physiological reviews
2001
Corpus ID: 16430392
The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite…
Expand
Highly Cited
1998
Highly Cited
1998
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*
M. Favata
,
K. Horiuchi
,
+11 authors
J. Trzăskos
The Journal of Biological Chemistry
1998
Corpus ID: 9896161
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1…
Expand
Highly Cited
1995
Highly Cited
1995
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)
D. Alessi
,
A. Cuenda
,
Philip R. Cohen
,
D. T. Dudley
,
A. Saltiel
The Journal of Biological Chemistry
1995
Corpus ID: 24032556
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1…
Expand
Highly Cited
1995
Highly Cited
1995
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
D. T. Dudley
,
L. Pang
,
S. Decker
,
A. Bridges
,
A. Saltiel
Proceedings of the National Academy of Sciences…
1995
Corpus ID: 34011286
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen…
Expand
Highly Cited
1995
Highly Cited
1995
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)
J. Raingeaud
,
Shashi Gupta
,
+4 authors
Roger J. Davis
The Journal of Biological Chemistry
1995
Corpus ID: 21563919
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK…
Expand
Review
1995
Review
1995
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*)
M. Karin
The Journal of Biological Chemistry
1995
Corpus ID: 9181673
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The…
Expand
Highly Cited
1995
Highly Cited
1995
Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
S. Kato
,
H. Endoh
,
+9 authors
P. Chambon
Science
1995
Corpus ID: 4662264
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER…
Expand
Highly Cited
1994
Highly Cited
1994
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
John C. Lee
,
J. Laydon
,
+15 authors
P. Young
Nature
1994
Corpus ID: 4306822
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE