FAQ

Mitogen-Activated Protein Kinases

Known as: Mitogen-Activated Protein Kinase, Map Kinase, Extracellular Signal-Regulated Kinases 
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and… (More)

Topic mentions per year

Topic mentions per year

1951-2018
020040060019512017

Related topics

Related topics

29 relations
Calcium-Calmodulin-Dependent Protein KinasesCalcium/calmodulin-dependent protein kinaseCell Cycle ControlCell Cycle Proteins
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Narrower (3)

MOK protein, humanMitogen-Activated Protein Kinase 3ZmMPK5

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Mitogen-Activated Protein Kinases
Signal Transduction
physiological aspects
Phosphotransferases
Cell Cycle Control
Protein phosphorylation

Papers overview

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Review
2016
Review
2016
Resistant mechanisms to BRAF inhibitors in melanoma.
Patients with advanced melanoma have traditionally had very poor prognosis. However, since 2011 better understanding of the… (More)
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Highly Cited
2008
Highly Cited
2008
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.
MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs… (More)
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Highly Cited
1999
Highly Cited
1999
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
The 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases play a pivotal role in the mitogenic signal transduction pathway… (More)
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Highly Cited
1998
Highly Cited
1998
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.
p38 mitogen-activated protein (MAP) kinase activities were significantly increased in mouse hearts after chronic transverse… (More)
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Highly Cited
1997
Highly Cited
1997
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
Mitogen-activated protein (MAP) kinases bind tightly to many of their physiologically relevant substrates. We have identified a… (More)
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Highly Cited
1997
Highly Cited
1997
Regulation of Cell Motility by Mitogen-activated Protein Kinase
Cell interaction with adhesive proteins or growth factors in the extracellular matrix initiates Ras/mitogen-activated protein… (More)
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Highly Cited
1997
Highly Cited
1997
Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors.
The transcription factors Elk-1 and SAP-1 bind together with serum response factor to the serum response element present in the c… (More)
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Highly Cited
1996
Highly Cited
1996
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and… (More)
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Highly Cited
1995
Highly Cited
1995
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… (More)
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Highly Cited
1993
Highly Cited
1993
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.
The mitogen-activated protein kinases (MAP kinases) p42mapk and p44mapk are serine/threonine kinases rapidly activated in cells… (More)
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