Mitogen-Activated Protein Kinase Kinases

Known as: Mitogen-Activated Protein Kinase Kinase, Mitogen Activated Protein Kinase Kinases, Kinase Kinase, Map 
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2017
05010015019742017

Papers overview

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Highly Cited
2007
Highly Cited
2007
PURPOSE The Ras-Raf-mitogen-activated protein kinase kinase (MEK) pathway is overactive in many human cancers and is thus a… (More)
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Highly Cited
2000
Highly Cited
2000
Despite the recognition of H(2)O(2) as a central signaling molecule in stress and wounding responses, pathogen defense, and… (More)
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Highly Cited
2000
Highly Cited
2000
TAK1, a member of the mitogen-activated kinase kinase kinase family, is activated in vivo by various cytokines, including… (More)
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Highly Cited
1999
Highly Cited
1999
The 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases play a pivotal role in the mitogenic signal transduction pathway… (More)
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Highly Cited
1998
Highly Cited
1998
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1… (More)
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Highly Cited
1998
Highly Cited
1998
A constitutively active form of mitogen-activated protein kinase kinase (MEK1) was synthesized under control of a zinc-inducible… (More)
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Highly Cited
1996
Highly Cited
1996
We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members… (More)
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Highly Cited
1995
Highly Cited
1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… (More)
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Highly Cited
1995
Highly Cited
1995
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino… (More)
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Highly Cited
1993
Highly Cited
1993
The guanosine triphosphate (GTP)-binding protein Ras functions in regulating growth and differentiation; however, little is known… (More)
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