Mitogen-Activated Protein Kinase Kinase Inhibitor

Known as: MAPK/ERK Kinase Inhibitor, MAPKK Inhibitor, MEK Inhibitor 
Any substance that inhibits mitogen-activated protein kinase kinase (MEK), an enzyme that catalyzes the addition of a phosphate group to a mitogen… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
05101519972017

Papers overview

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2016
2016
PURPOSE Tumor-derived circulating cell-free DNA (cfDNA) is a potential alternative source from which to derive tumor mutation… (More)
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2016
2016
UNLABELLED KRAS is frequently mutated in lung cancer. Whereas MAPK is a well-known effector pathway of KRAS, blocking this… (More)
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2016
2016
PURPOSE Though the efficacy of MEK inhibitors is being investigated in KRAS-mutant colorectal cancers (CRC), early clinical… (More)
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2015
2015
BACKGROUND This phase Ib trial investigated the safety, tolerability, and recommended phase II dose and schedule of the MEK… (More)
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2014
2014
BRAF-mutant melanoma can be successfully treated by BRAF kinase inhibitors (BRAFi) and MEK kinase inhibitors (MEKi). However, the… (More)
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2014
2014
BACKGROUND Trametinib, an oral mitogen/extracellular signal-related kinase (MEK)1/2 inhibitor, holds promise for malignancies… (More)
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2014
2014
Keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cuSCCs) develop in 15-30% of patients with BRAF(V600E) metastatic… (More)
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2011
2011
AZD6244 is a small molecule inhibitor of the MEK (MAP/ERK kinase) pathway currently in clinical trials. However, the mechanisms… (More)
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2008
2008
Lung caner cells have a striking tendency to metastasize to bone. The chemokine stromal cell-derived factor-1 (SDF-1) is… (More)
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2003
2003
The roles of extracellular regulated kinase (ERK) activation and mitogen-activated protein kinase phosphatase-1 (MKP-1) were… (More)
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