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Mitogen-Activated Protein Kinase Inhibitor

Known as: MAPK Inhibitors 
Any substance that inhibits mitogen-activated protein kinase (MAPK), an enzyme that catalyzes the addition of a phosphate group to a protein in the… Expand
National Institutes of Health

Papers overview

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2018
2018
Melanoma resistant to MAPK inhibitors (MAPKi) displays loss of fitness upon experimental MAPKi withdrawal and, clinically, may be… Expand
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Highly Cited
2016
Highly Cited
2016
Targeting multiple components of the MAPK pathway can prolong the survival of patients with BRAFV600E melanoma. This approach is… Expand
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Highly Cited
2016
Highly Cited
2016
Abstract Targeted therapies with MAPK inhibitors (MAPKi) are faced with severe problems of resistance in BRAF‐mutant melanoma. In… Expand
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Highly Cited
2014
Highly Cited
2014
Background MAPK inhibitors (MAPKi) are active in BRAF-mutant metastatic melanoma patients, but the extent of response and… Expand
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2013
2013
In almost all vertebrates, the downstream of the sox9 signaling axis is well conserved for testis differentiation. The upstream… Expand
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2010
2010
Objectives: We investigated whether the recovery of cultured human islets is improved through the addition of a p38&agr… Expand
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Highly Cited
2008
Highly Cited
2008
P38α is a protein kinase that regulates the expression of inflammatory cytokines, suggesting a role in the pathogenesis of… Expand
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2008
2008
Histone deacetylase inhibitors have emerged as promising anticancer drugs. Using an unbiased ultrahigh throughput screening… Expand
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2001
2001
OBJECTIVE Osteoarthritis (OA) involves both a decreased reparative process and an increased degradative phenomenon. Several… Expand
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Highly Cited
2001
Highly Cited
2001
Signaling pathway components mediating Epstein-Barr virus (EBV) reactivation by 12-O-tetradecanoylphorbol-13-acetate (TPA) were… Expand
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