Mitogen Activated Protein Kinase 1

Known as: p42(Mapk), MAPK2 Mitogen-Activated Protein Kinase, MAPK 1 
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Several microRNAs (miRs) have been shown to regulate gene expression in the heart, and dysregulation of their… (More)
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Highly Cited
2012
Highly Cited
2012
The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors is limited by the development of drug… (More)
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Highly Cited
2011
Highly Cited
2011
Autophagy is a cellular catabolic process that relies on the cooperation of autophagosomes and lysosomes. During starvation, the… (More)
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Highly Cited
2007
Highly Cited
2007
Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake, fatty acid oxidation, and mitochondrial… (More)
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Highly Cited
2001
Highly Cited
2001
Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the… (More)
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Highly Cited
1998
Highly Cited
1998
PD98059, a specific inhibitor of MEK-1 mitogen-activated protein (MAP) kinase kinase, blocked Listeria monocytogenes invasion… (More)
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Highly Cited
1997
Highly Cited
1997
Migration of vascular smooth muscle cells (VSMCs) is a crucial response to vascular injury resulting in neointima formation and… (More)
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Highly Cited
1995
Highly Cited
1995
The thin-filament protein h-caldesmon (the high molecular weight isoform of caldesmon) is phosphorylated in resting and… (More)
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Highly Cited
1994
Highly Cited
1994
The translocation of protein kinase C (PKC) isoforms PKC-alpha, PKC-delta, PKC-epsilon, and PKC-zeta from soluble to particulate… (More)
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Highly Cited
1993
Highly Cited
1993
Mitogenic stimulation of cells induces rapid and transient activation of MAP kinases. Here we report that a growth factor… (More)
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