Mitochondrial Degradation

Known as: Degradation, Mitochondrial, Mitophagy, mitochondrion autophagy 
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions. [GOC:autophagy… (More)
National Institutes of Health

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aspects of radiation effectsnegative regulation of mitophagyphysiological aspectspositive regulation of mitophagy
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are… (More)
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Review
2017
Review
2017
Neuronal Mitophagy in Neurodegenerative Diseases
Neuronal homeostasis depends on the proper functioning of different quality control systems. All intracellular components are… (More)
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Highly Cited
2011
Highly Cited
2011
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane.
Upon mitochondrial depolarization, Parkin, a Parkinson disease-related E3 ubiquitin ligase, translocates from the cytosol to… (More)
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Highly Cited
2010
Highly Cited
2010
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of genes linked to familial forms of PD… (More)
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Highly Cited
2010
Highly Cited
2010
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Damage to mitochondria can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired… (More)
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Highly Cited
2010
Highly Cited
2010
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson's disease. It has been found to work in the same… (More)
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Highly Cited
2010
Highly Cited
2010
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology… (More)
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Highly Cited
2009
Highly Cited
2009
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-induced kinase 1 (PINK1) are… (More)
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Highly Cited
2009
Highly Cited
2009
Atg32 is a mitochondrial protein that confers selectivity during mitophagy.
Mitochondrial quality control is important in maintaining proper cellular homeostasis. Although selective mitochondrial… (More)
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Highly Cited
2005
Highly Cited
2005
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging.
In autophagy, portions of cytoplasm are sequestered into autophagosomes and delivered to lysosomes for degradation. Long assumed… (More)
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