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Minibody

An engineered antibody comprised of a dimeric complex consisting of two immunoglobulin fragments. Each fragment consists of a single chain variable… 
National Institutes of Health

Papers overview

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2018
2018
Imaging of tumor infiltrating T cells with an anti-CD8 minibody (Mb) 89Zr-IAB22M2C, in advanced solid tumors.
e24160Background: The degree of tumor infiltration by CD8 T cells is associated with favorable outcomes to immunotherapy… 
2014
2014
Numerical comparison of iodine-based and indium-based antibody biodistributions.
PURPOSE Single-step iodination is often performed in preference to use of a radiometal label for initial animal biodistributions… 
2010
2010
Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity.
This case study describes early phase purification process development for a recombinant anticancer minibody produced in… 
2009
2009
Recombinant Anti-CD 20 Antibody Fragments for Small-Animal PET Imaging of B-Cell Lymphomas
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine… 
2007
2007
Cytotoxic effects of T cells induced by fusion protein 6B11-pulsed dendritic cells on ovarian carcinoma cells.
2004
2004
Bispecific Minibodies Targeting HER 2 / neu and CD 16 Exhibit Improved Tumor Lysis When Placed in a Divalent Tumor Antigen
Unconjugated monoclonal antibodies have emerged as important therapeutic agents for selected malignancies. One mechanism by which… 
Review
2001
Review
2001
Of minibody, camel and bacteriophage.
This review describes the design process from conception through realisation and optimisation of a minibody'--a minimised… 
2000
2000
Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies.
Targeting of monoclonal antibody (Mab) to solid tumor sites is a function of the blood curve of activity versus time. It has been… 
1999
1999
A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody.
We have been interested for some time in establishing a strategy for deriving lead compounds from macromolecule ligands such as… 
1994
1994
The making of the minibody: An engineered β‐protein for the display of conformationally constrained peptides
Conformationally constraining selectable peptides onto a suitable scaffold that enables their conformation to be predicted or… 
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